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Product Info Summary
| SKU: | A15239 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Rkhd4 MEX3A Antibody
SKU/Catalog Number
A15239
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Rkhd4 MEX3A Antibody (Catalog # A15239). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Rkhd4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Rkhd4 MEX3A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A15239)
Host
Rabbit
Contents
Rkhd4 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rkhd4 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Rkhd4. The immunogen is located within amino acids 420 - 470 of Rkhd4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This Spred3 antibody is predicted to have no cross-reactivity to Spred1 or Spred2.
Reactive Species
A15239 is reactive to MEX3A in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
54173 MW
Background of MEX3A
Rkhd4, also known as MEX3A is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd4, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. While Rkhd2 has been suggested to be associated with susceptibility to essential hypertension type 8, the function of Rkhd4 remains unknown. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A15239 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Rkhd4 antibody can be used for detection of Rkhd4 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Rkhd4 in SK-N-SH cell lysate with Rkhd4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of Rkhd4 in human brain tissue with Rkhd4 antibody at 2.5 μg/mL.
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Immunofluorescence of rkhd4 in human brain tissue with rkhd4 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For MEX3A (Source: Uniprot.org, NCBI)
Gene Name
MEX3A
Full Name
RNA-binding protein MEX3A
Weight
54173 MW
Alternative Names
RKHD4, MEX-3A, RKHD4, RNA-binding protein MEX3A, RING finger and KH domain-containing protein 4 MEX3A MEX-3A, RKHD4, RNF162 mex-3 RNA binding family member A RNA-binding protein MEX3A|RING finger and KH domain-containing protein 4|ring finger and KH domain containing 4|ring finger and KH domain containing protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MEX3A, check out the MEX3A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MEX3A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Rkhd4 MEX3A Antibody (A15239)
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