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Tested in WB applications. This antibody reacts with Human. Supplied as 100μg/vial in Lyophilized form antibody. Key=image, value=/antibody/pa2242-1-WB-anti-rip3-antibody.jpg Key=small_image, value=/antibody/pa2242-1-WB-anti-rip3-antibody.jpg Key=thumbnail, value=/antibody/pa2242-1-WB-anti-rip3-antibody.jpg Key=url_key, value=anti-rip3-antibody-pa2242-boster Key=url_path, value=anti-rip3-antibody-pa2242-boster Key=options_container, value=Product Info Column Key=image_label, value=Anti-RIP3 antibody, PA2242, Western blotting Lane 1: PANC Cell Lysate Lane 2: SW620 Cell Lysate Lane 3: SKOV-3 Cell Lysate Lane 4: M231 Cell Lysate Key=small_image_label, value=Anti-RIP3 antibody, PA2242, Western blotting Lane 1: PANC Cell Lysate Lane 2: SW620 Cell Lysate Lane 3: SKOV-3 Cell Lysate Lane 4: M231 Cell Lysate Key=thumbnail_label, value=Anti-RIP3 antibody, PA2242, Western blotting Lane 1: PANC Cell Lysate Lane 2: SW620 Cell Lysate Lane 3: SKOV-3 Cell Lysate Lane 4: M231 Cell Lysate Key=msrp_display_actual_price_type, value=Use config Key=gift_message_available, value=No Key=size, value=100 μg/vial Key=protein_name, value=Receptor-interacting serine/threonine-protein kinase 3 Key=gene_full_name, value=Receptor-interacting serine/threonine-protein kinase 3 Key=uniprot_id, value=Q9Y572 Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml. Key=sensitivity Key=applications, value=WB Key=reactivity, value=Human Key=form, value=Lyophilized Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. Key=cross_reactivity, value=No cross-reactivity with other proteins Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot. Key=source_company, value=Boster PA2242 Key=isotype, value=Rabbit IgG Key=molecular_weight, value=56887 MW Key=sample_size_available, value=30ug for $99, contact us for details Key=related_product_skus, value=B0001-5,AR1156,AR0146 Key=product_category, value=Primary Antibodies Key=research_category, value=Apoptosis, Associated Proteins, Cancer, Cell Biology, Cell Death, Immunology, Innate Immunity, Intracellular, Kinases, Protein Phosphorylation, Receptors, Ser/Thr Kinases, Signal Transduction, TLR Signaling Key=clonality, value=Polyclonal Key=swatch_image, value=/antibody/ek0685-2-ELISA-mouse-ccl17-tarc-picokine-elisa-kit.jpg Key=rating_value, value=98.8 Key=review_count, value=13 Key=mp_exclude_sitemap, value=No Key=yoast_focus_keyword, value=CD68 antibody Key=yoast_facebook_image, value=/p/a/pa1787-2-hexa-primary-antibodies-wb-testing-1_1.jpg Key=yoast_twitter_image, value=/p/a/pa1787-2-hexa-primary-antibodies-wb-testing-1_1.jpg Key=cj_related_products, value=Necroptosis:M00202-1|A00237S191|A00237-4|A01403-Dyl550^Pancreatitis:M01421-2|M01421-3 Key=description, value=Boster Bio Anti-RIP3/RIPK3 Antibody catalog # PA2242. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance. Key=short_description, value=Boster Bio Anti-RIP3/RIPK3 Antibody catalog # PA2242. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance. Key=meta_keyword, value=Anti-RIP3/RIPK3 Antibody Key=contents, value=Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Key=background, value=Receptor-interacting serine/threonine-protein kinase 3 (RIPK3), also known as RIP3 is an enzyme that in humans is encoded by the RIPK3 gene. This gene is mapped to 14q12. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. Key=gene_name, value=RIPK3 Key=synonyms, value=Receptor-interacting serine/threonine-protein kinase 3;2.7.11.1;RIP-like protein kinase 3;Receptor-interacting protein 3;RIP-3;RIPK3;RIP3; Key=application_details, value=Western blot, 0.1-0.5μg/ml, Human
Key=subcellular_localization, value= Cytoplasm, cytosol . Cell membrane . Mitochondrion . Key=sequence_similarities, value=Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Key=tissue_specificity, value= Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. . Key=protein_function, value= Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. . Key=application_notes, value=Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
Key=competitor_equivalent_skus, value=sc 135170|sc 135171|sc 374639|sc 47368|sc 56228 Key=immunogen, value=A synthetic peptide corresponding to a sequence at the N-terminus of human RIP3. Key=purification, value=Immunogen affinity purified. Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles. Key=custom_attribute_1, value=56 kDa, 77 kDa Key=custom_attribute_2, value=WB: PANC Cell, SW620 Cell, SKOV-3 Cell, M231 Cell Key=custom_attribute_3, value=BA3486-2 Key=options Key=media_gallery Key=extension_attributes Key=tier_price Key=tier_price_changed Key=category_ids Key=is_salable Key=website_ids Key=request_path Key=rating_summary Key=_cache_instance_store_filter Key=media_gallery_images
Anti-RIP3/RIPK3 Antibody Picoband®
RIPK3/RIP3 antibody
Boster Bio Anti-RIP3/RIPK3 Antibody catalog # PA2242. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance. Cited in 1 publication(s).
Boster Bio Anti-RIP3/RIPK3 Antibody catalog # PA2242. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-RIP3/RIPK3 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2242)
A synthetic peptide corresponding to a sequence at the N-terminus of human RIP3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA2242 is reactive to RIPK3 in Human
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Observed Molecular Weight
56 kDa, 77 kDa
Calculated molecular weight
56887 MW
Background of RIPK3/RIP3
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3), also known as RIP3 is an enzyme that in humans is encoded by the RIPK3 gene. This gene is mapped to 14q12. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Receptor-interacting serine/threonine-protein kinase 3;2.7.11.1;RIP-like protein kinase 3;Receptor-interacting protein 3;RIP-3;RIPK3;RIP3; RIPK3 RIP3 receptor interacting serine/threonine kinase 3 receptor-interacting serine/threonine-protein kinase 3|RIP-3|RIP-like protein kinase 3|receptor interacting protein 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".
For more info on RIPK3, check out the RIPK3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for RIPK3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Smad3-Targeted Therapy Protects against Cisplatin-Induced AKI by Attenuating Programmed Cell Death and Inflammation via a NOX4-Dependent Mechanism. Qin Yang,Li Gao,Xiao-wei Hu,Jia-nan Wang,Yao Zhang,Yu-hang Dong,Hui Yao Lan,Xiao-ming Meng Species: Mouse PA2242 usage in article: APP:WB, SAMPLE:KIDNEY TISSUE, DILUTION:NA
4 Customer Q&As for Anti-RIP3/RIPK3 Antibody Picoband®
Question
We are currently using anti-RIP3/RIPK3 antibody PA2242 for human tissue, and we are satisfied with the WB results. The species of reactivity given in the datasheet says human. Is it true that the antibody can work on feline tissues as well?
Verified Customer
Verified customer
Asked: 2019-12-23
Answer
The anti-RIP3/RIPK3 antibody (PA2242) has not been tested for cross reactivity specifically with feline tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in feline you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2019-12-23
Question
Our team were happy with the WB result of your anti-RIP3/RIPK3 antibody. However we have observed positive staining in aortic endothelium fetal brain cytosol using this antibody. Is that expected? Could you tell me where is RIPK3 supposed to be expressed?
L. Miller
Verified customer
Asked: 2019-08-05
Answer
Based on literature, aortic endothelium fetal brain does express RIPK3. Generally RIPK3 expresses in cytoplasm, cytosol. Regarding which tissues have RIPK3 expression, here are a few articles citing expression in various tissues: Aortic endothelium, and Fetal brain, Pubmed ID: 10358032 Blood, Pubmed ID: 15489334 Cervix carcinoma, and Lymphocyte, Pubmed ID: 10339433 Thalamus, Pubmed ID: 14702039
Boster Scientific Support
Answered: 2019-08-05
Question
We have been able to see staining in human blood. Any tips? Is anti-RIP3/RIPK3 antibody supposed to stain blood positively?
Verified Customer
Verified customer
Asked: 2019-05-09
Answer
According to literature blood does express RIPK3. According to Uniprot.org, RIPK3 is expressed in blood, cervix carcinoma lymphocyte, aortic endothelium fetal brain, thalamus, among other tissues. Regarding which tissues have RIPK3 expression, here are a few articles citing expression in various tissues: Aortic endothelium, and Fetal brain, Pubmed ID: 10358032 Blood, Pubmed ID: 15489334 Cervix carcinoma, and Lymphocyte, Pubmed ID: 10339433 Thalamus, Pubmed ID: 14702039
Boster Scientific Support
Answered: 2019-05-09
Question
We need using your anti-RIP3/RIPK3 antibody for thymus development studies. Has this antibody been tested with western blotting on sw620 cell lysate? We would like to see some validation images before ordering.
Verified Customer
Verified customer
Asked: 2017-08-25
Answer
Thanks for your inquiry. This PA2242 anti-RIP3/RIPK3 antibody is validated on panc cell lysate, sw620 cell lysate, m231 cell lysate. It is guaranteed to work for WB in human. Our Boster guarantee will cover your intended experiment even if the sample type has not been be directly tested.
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00
Troubleshooting
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