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Product Info Summary
| SKU: | A01066 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IF, IHC, WB |
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Product info
Product Name
Anti-Pyk2(Ab-402) PTK2B Antibody
SKU/Catalog Number
A01066
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-Pyk2(Ab-402) PTK2B Antibody (Catalog # A01066). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Pyk2(Ab-402) PTK2B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01066)
Host
Rabbit
Contents
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Peptide sequence around aa.400~404 (D-I-Y-A-E) derived from Human Pyk2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01066 is reactive to PTK2B in Human, Mouse, Rat
Reconstitution
Calculated molecular weight
115875 MW
Background of PYK2/FAK2
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
Gluck SL, et al. (2004) J Clin Invest; 114(12): 1696-1699
Benzing T, et al. (2001) Proc Natl Acad Sci U S A; 98(17): 9784-9789
Tian D, et al. (2002) Mol Cell Biol; 22(8): 2650-2662
Lu Z, et al. (2001) Mol Cell Biol; 21(12): 4016-4031
Krishnan HH, et al. (2006) J Virol; 80(3): 1167-1180
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01066 is guaranteed for IF, IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Predicted MW: 140kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
Validation Images & Assay Conditions
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Pyk2(Ab-402) antibody A01066(left) or the same antibody preincubated with blocking peptide(right).
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Western blot analysis of extracts from 293 cells using Pyk2(Ab-402) antibody A01066.
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Immunofluorescence staining of methanol-fixed Hela cells using Pyk2(Ab-402) antibody A01066.
Protein Target Info & Infographic
Gene/Protein Information For PTK2B (Source: Uniprot.org, NCBI)
Gene Name
PTK2B
Full Name
Protein-tyrosine kinase 2-beta
Weight
115875 MW
Superfamily
protein kinase superfamily
Alternative Names
Protein-tyrosine kinase 2-beta;2.7.10.2;Calcium-dependent tyrosine kinase;CADTK;Calcium-regulated non-receptor proline-rich tyrosine kinase;Cell adhesion kinase beta;CAK-beta;CAKB;Focal adhesion kinase 2;FADK 2;Proline-rich tyrosine kinase 2;Related adhesion focal tyrosine kinase;RAFTK;PTK2B;FAK2, PYK2, RAFTK; PTK2B CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK protein tyrosine kinase 2 beta protein-tyrosine kinase 2-beta|CAK-beta|FADK 2|PTK2B protein tyrosine kinase 2 beta|calcium-dependent tyrosine kinase|calcium-regulated non-receptor proline-rich tyrosine kinase|cell adhesion kinase beta|focal adhesion kinase 2|proline-rich tyrosine kinase 2|protein kinase B|related adhesion focal tyrosine kinase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PTK2B, check out the PTK2B Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PTK2B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Pyk2(Ab-402) PTK2B Antibody (A01066)
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