Product Info Summary
SKU: | A00575-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat, Zebrafish |
Host: | Rabbit |
Application: | Flow Cytometry, IHC, ICC, WB |
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Product info
Product Name
Anti-Protein-lysine 6-oxidase LOX Antibody
SKU/Catalog Number
A00575-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Protein-lysine 6-oxidase LOX Antibody catalog # A00575-1. Tested in WB,ICC,IHC,Flow Cytometry applications. This antibody reacts with Human,Mouse,Rat,Zebrafish.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Protein-lysine 6-oxidase LOX Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00575-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human CaSR around the phosphorylation site of T888.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00575-1 is reactive to LOX in Human, Mouse, Rat, Zebrafish
Applications
A00575-1 is guaranteed for Flow Cytometry, IHC, ICC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
46944 MW
Background of Lox
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes By similarity. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Nagamine K., Nat. Genet. 17:393-398(1997).
Aaltonen J., Nat. Genet. 17:399-403(1997).
Hattori M., Nature 405:311-319(2000).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2,000
ICC: 1:100-1:500
IHC: 1:50-1:100
FC: 1:50-1:100
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunocytochemistry staining of LOX using Anti-Protein-lysine 6-oxidase LOX Antibody (A00575-1).
ICC staining LOX in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeClick image to see more details
Figure 1. Western blotting validation for Anti-Protein-lysine 6-oxidase LOX Antibody A00575-1
Western blot analysis of LOX on different lysates using anti-LOX antibody at 1/1Protein Target Info & Infographic
Gene/Protein Information For LOX (Source: Uniprot.org, NCBI)
Gene Name
LOX
Full Name
Protein-lysine 6-oxidase
Weight
46944 MW
Superfamily
lysyl oxidase family
Alternative Names
AAT10; LOX; lysyl oxidaseEC 1.4.3.13; MGC105112; protein-lysine 6-oxidase LOX AAT10 lysyl oxidase protein-lysine 6-oxidase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LOX, check out the LOX Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LOX: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Protein-lysine 6-oxidase LOX Antibody (A00575-1)
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