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Product Info Summary
| SKU: | A04406 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Protein bicaudal D homolog 2 BICD2 Antibody
SKU/Catalog Number
A04406
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Protein bicaudal D homolog 2 BICD2 Antibody (Catalog # A04406). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
BICD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Protein bicaudal D homolog 2 BICD2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04406)
Host
Rabbit
Contents
BICD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
BICD2 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human BICD2. The immunogen is located within the last 50 amino acids of BICD2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This BICD2 antibody will not cross-react with BICD1.
Reactive Species
A04406 is reactive to BICD2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
93533 MW
Background of BICD2
BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04406 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
BICD2 antibody can be used for detection of BICD2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of BICD2 in A549 cell lysate with BICD2 antibody at (A) 1 and (B) 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For BICD2 (Source: Uniprot.org, NCBI)
Gene Name
BICD2
Full Name
Protein bicaudal D homolog 2
Weight
93533 MW
Superfamily
BicD family
Alternative Names
SMALED2, bA526D8.1, KIAA0699, Protein bicaudal D homolog 2, Bic-D 2 BICD2 SMALED2, SMALED2A, SMALED2B, bA526D8.1 BICD cargo adaptor 2 protein bicaudal D homolog 2|bic-D 2|bicaudal D homolog 2|coiled-coil protein BICD2|cytoskeleton-like bicaudal D protein homolog 2|homolog of Drosophila bicaudal D
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on BICD2, check out the BICD2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for BICD2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Protein bicaudal D homolog 2 BICD2 Antibody (A04406)
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