Anti-Presenilin 2/PSEN2 Antibody Picoband®

Product Name

Anti-Presenilin 2/PSEN2 Antibody Picoband®

View all Presenilin-2 Antibodies

SKU/Catalog Number

PA1358

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Presenilin 2/PSEN2 Antibody catalog # PA1358. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Presenilin 2/PSEN2 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1358)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2, different from the related mouse and rat sequences by two amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1358 is reactive to PSEN2 in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

60 kDa

Calculated molecular weight

50140 MW

Background of Presenilin-2

Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1358 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Positive Control

WB: Rat Brain Tissue, Rat Brain Tissue, MCF-7 Cell, HELA Cell, SMMC Cell, CEM Cell
IHC: Human Mammary Cancer Tissue, Rat Cardiac Muscle Tissue, Rat Kidney Tissue

Validation Images & Assay Conditions

Gene/Protein Information For PSEN2 (Source: Uniprot.org, NCBI)

Alternative Names

Presenilin-2;PS-2;3.4.23.-;AD3LP;AD5;E5-1;STM-2;Presenilin-2 NTF subunit;Presenilin-2 CTF subunit;PSEN2;AD4, PS2, PSNL2, STM2; PSEN2 AD3L, AD4, CMD1V, PS2, STM2 presenilin 2 presenilin-2|AD3LP|AD5|Alzheimer disease 4|E5-1|PS-2|STM-2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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