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Presenilin-2 Antibodies
AND PSEN2 ELISA kits, Presenilin-2 Proteins
Many biological assays use antibodies to detect Presenilin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Presenilin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Presenilin-2 antibodies...
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PSEN2 Infographic by Boster Bio
All PSEN2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1358
100 μg/vial
Cat # PA1358
100 μg/vial
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00800S330
100ul
Cat # A00800S330
100ul
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00800
100 μg/vial
Cat # A00800
100 μg/vial
PSEN2 Overview
Facts about Presenilin-2.
Presenilin-2 (PSEN2)
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of this gamma-secretase complex to have a protease activity.
May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | PSEN2 |
| Uniprot: | P49810 |
| Entrez: | 5664 |
Family
| Belongs to: |
|---|
| peptidase A22A family |
Alternative Names
AD3LP; AD4AD3L; AD5; E5-1; EC 3.4.23; EC 3.4.23.-; presenilin 2 (Alzheimer disease 4); Presenilin2; Presenilin-2; PS-2; PS2CMD1V; PSEN2; PSNL2; STM2STM-2
Molecular Weight
Mass (kDA):
50.14 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q42.13 |
| Sequence: | 1; NC_000001.11 (226870572..226903829) |
Tissue Specificity
Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Diseases
- Alzheimer's Disease
- Alzheimer Disease, Familial
- Dementia
- Neurodegenerative Disorders
- Neurofibrillary Tangles
- Plaque, Amyloid
- Senile Plaques
- Nerve Degeneration
- Malignant Neoplasms
- Neuroblastoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Impaired Cognition
Interacting Proteins
- DYNC1H1
- ECSIT
- PDCD4
Pathways
- Pathogenesis
- Proteolysis
- Cell Death
- Localization
- Secretion
- Transport
- Aging
- Programmed Cell Death
- Cell Proliferation
- Protein Processing
- Cell Cycle
- Rna Interference
- Translation
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Gamma-cleavage
- Methylation
- Biotinylation
- Dephosphorylation
Research Areas
- Alzheimers Research
- Apoptosis
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSEN2
bosterbio.com/bosterbio-gene-info-cards/PSEN2
References
PMID: 7638622 by Levy-Lahad E., et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus.
PMID: 7651536 by Rogaev E.I., et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene.