Product Info Summary
SKU: | A00093 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | IF, IHC, WB |
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Product info
Product Name
Anti-PML (P39) Antibody
View all PML Protein Antibodies
SKU/Catalog Number
A00093
Size
100ul
Form
Liquid
Description
Boster Bio Anti-PML (P39) Antibody catalog # A00093. Tested in WB,IHC,IF applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-PML (P39) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00093)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Smad2 around the phosphorylation site of T220.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A00093 is reactive to PML in Human
Applications
A00093 is guaranteed for IF, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
97551 MW
Background of PML Protein
Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase. Anti-Beta Amyloid Antibody is useful for researchers interested in TLR signaling and Alzheimer's research.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
IHC: 1:50-1:200
IF: 1:50-1:200
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For PML (Source: Uniprot.org, NCBI)
Gene Name
PML
Full Name
Protein PML
Weight
97551 MW
Alternative Names
MYLPP8675; Promyelocytic leukemia protein; promyelocytic leukemia; RING finger protein 71; RNF71probable transcription factor PML; TRIM19promyelocytic leukemia, inducer of; tripartite motif protein TRIM19; Tripartite motif-containing protein 19 PML MYL, PP8675, RNF71, TRIM19 PML nuclear body scaffold protein PML|PML/RARA fusion|RING finger protein 71|probable transcription factor PML|promyelocytic leukemia protein|promyelocytic leukemia, inducer of|tripartite motif protein TRIM19|tripartite motif-containing protein 19
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PML, check out the PML Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PML: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PML (P39) Antibody (A00093)
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No publications found for A00093
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