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Product Info Summary
| SKU: | A09234-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-Phospholipase A1 member A PLA1A Antibody
SKU/Catalog Number
A09234-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Phospholipase A1 member A PLA1A Antibody (Catalog # A09234-1). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Rat.
Storage & Handling
PLA1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Phospholipase A1 member A PLA1A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09234-1)
Host
Rabbit
Contents
PLA1A Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PLA1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human PLA1A. The immunogen is located within amino acids 380 - 430 of PLA1A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of PLA1A are known to exist; this antibody will detect all three isoforms.
Reactive Species
A09234-1 is reactive to PLA1A in Human, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
49715 MW
Background of PLA1A
PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09234-1 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PLA1A antibody can be used for detection of PLA1A by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PLA1A in human kidney tissue lysate with PLA1A antibody at (A) 1 and (B) 2 μg/mL.
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Immunofluorescence of PLA1A in human kidney tissue with PLA1A antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PLA1A (Source: Uniprot.org, NCBI)
Gene Name
PLA1A
Full Name
Phospholipase A1 member A
Weight
49715 MW
Superfamily
AB hydrolase superfamily
Alternative Names
PSPLA1, PS-PLA1, NMD, PSPLA1, Phospholipase A1 member A, Phosphatidylserine-specific phospholipase A1 PLA1A PS-PLA1, PSPLA1 phospholipase A1 member A phospholipase A1 member A|phosphatidylserine-specific phospholipase A1alpha
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PLA1A, check out the PLA1A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PLA1A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Phospholipase A1 member A PLA1A Antibody (A09234-1)
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