Phospholipase A1 member A Antibodies

Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and generates 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the kind of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI).

Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.