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Product Info Summary
| SKU: | A06811-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-PACS1 Antibody
SKU/Catalog Number
A06811-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PACS1 Antibody (Catalog # A06811-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
PACS1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-PACS1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06811-1)
Host
Rabbit
Contents
PACS1 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PACS1 antibody was raised against a 17 amino acid peptide near the center of human PACS1. The immunogen is located within amino acids 430 - 480 of PACS1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
PACS1 antibody is human, mouse and rat reactive. Multiple isoforms of PACS1 are known to exist. PACS1 antibody is predicted to not cross-react with PACS2.
Reactive Species
A06811-1 is reactive to PACS1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
104898 MW
Background of PACS1
The phosphofurin acidic cluster sorting protein 1 (PACS1), belongs to the PACS family of cytosolic connector proteins that localize different membrane proteins to the trans-Golgi network (TGN) (1,2). Mutations in PACS1 cause defects in cranial-neural crest migration during early development, leading to a recognizable intellectual disability syndrome (3). PACS1, along with the related protein PACS2, also plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06811-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PACS1 antibody can be used for detection of PACS1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2 μg/mL For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PACS1 in rat bladder tissue lysate with PACS1 antibody at 1 μg/ml.
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Immunohistochemistry of PACS1 in mouse brain tissue with PACS1 antibody at 2 μg/ml.
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Immunofluorescence of PACS1 in human bladder tissue with PACS1 antibody at 20 μg/mL.
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Immunofluorescence of PACS1 in mouse brain tissue with PACS1 antibody at 20 μg/ml.
Green: PACS1 Antibody (A06811-1)
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For PACS1 (Source: Uniprot.org, NCBI)
Gene Name
PACS1
Full Name
Phosphofurin acidic cluster sorting protein 1
Weight
104898 MW
Superfamily
PACS family
Alternative Names
Phosphofurin acidic cluster sorting protein 1, PACS-1, MRD17 PACS1 MRD17, SHMS phosphofurin acidic cluster sorting protein 1 phosphofurin acidic cluster sorting protein 1|PACS-1|cytosolic sorting protein PACS-1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PACS1, check out the PACS1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PACS1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PACS1 Antibody (A06811-1)
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