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Product Info Summary
| SKU: | A01941 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-OMI HTRA2 Antibody
SKU/Catalog Number
A01941
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-OMI HTRA2 Antibody (Catalog # A01941). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
OMI antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-OMI HTRA2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01941)
Host
Rabbit
Contents
OMI Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
OMI antibody was raised against a peptide corresponding to 16 amino acids near the C-terminus of human Omi. The immunogen is located within amino acids 70 - 120 of OMI.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SRPK1 antibody is human, mouse and rat reactive. Multiple isoforms of SRPK1 are known to exist; this antibody will detect all except isoforms b and e. SRPK1 antibody is predicted to not cross-react with SRPK2.
Reactive Species
A01941 is reactive to HTRA2 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
48841 MW
Background of HTRA2/Omi
Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication. Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases. The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs. Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs. Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01941 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
OMI antibody can be used for detection of OMI by Western blot at 0.5 to 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of OMI in U937 lysate with Omi antibody at (A) 0.5
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Immunohistochemistry of OMI in human liver tissue with OMI antibody at 2 μg/mL.
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Immunofluorescence of OMI in Human Liver cells with OMI antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For HTRA2 (Source: Uniprot.org, NCBI)
Gene Name
HTRA2
Full Name
Serine protease HTRA2, mitochondrial
Weight
48841 MW
Superfamily
peptidase S1C family
Alternative Names
OMI, PARK13, PRSS25, OMI, Serine protease HTRA2, mitochondrial, High temperature requirement protein A2, HtrA2 HTRA2 MGCA8, OMI, PARK13, PRSS25 HtrA serine peptidase 2 serine protease HTRA2, mitochondrial|HtrA-like serine protease|Omi stress-regulated endoprotease|epididymis secretory sperm binding protein|high temperature requirement protein A2|protease, serine, 25|serine protease 25|serine proteinase OMI
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HTRA2, check out the HTRA2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HTRA2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-OMI HTRA2 Antibody (A01941)
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