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Key=updated_at, value=2024-09-26 00:46:55
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Key=template, value=antibodies
Key=host, value=Rabbit
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Key=yoast_keyword_score, value=-1365
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Key=meta_title, value=Anti-NUR77/NR4A1 Antibody Picoband® | Bosterbio
Key=meta_description, value=Boster Bio Anti-NUR77/NR4A1 Antibody Picoband® catalog # PB9766. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100μg/vial in Lyophilized form antibody.
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Key=image_label, value=Anti- NUR77 Picoband antibody, PB9766, Western blotting
All lanes: Anti NUR77 (PB9766) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Mouse Brain Tissue Lysate at 50ug
Lane 3: U87 Whole Cell Lysate at 40ug
Lane 4: HELA Whol
Key=small_image_label, value=Anti- NUR77 Picoband antibody, PB9766, Western blotting
All lanes: Anti NUR77 (PB9766) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Mouse Brain Tissue Lysate at 50ug
Lane 3: U87 Whole Cell Lysate at 40ug
Lane 4: HELA Whol
Key=thumbnail_label, value=Anti- NUR77 Picoband antibody, PB9766, Western blotting
All lanes: Anti NUR77 (PB9766) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Mouse Brain Tissue Lysate at 50ug
Lane 3: U87 Whole Cell Lysate at 40ug
Lane 4: HELA Whol
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Key=size, value=100 μg/vial
Key=protein_name, value=Nuclear receptor subfamily 4 group A member 1
Key=gene_full_name, value=Nuclear receptor subfamily 4 group A member 1
Key=uniprot_id, value=P22736
Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Key=sensitivity
Key=applications, value=WB
Key=reactivity, value=Human, Mouse, Rat
Key=form, value=Lyophilized
Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Key=cross_reactivity, value=No cross-reactivity with other proteins.
Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
Key=predicted_reactivity
Key=source_company, value=Boster PB9766
Key=isotype, value=Rabbit IgG
Key=molecular_weight, value=64463 MW
Key=sample_size_available, value=30ug for $99, contact us for details
Key=related_product_skus, value=B0001-5,AR1156,AR0146
Key=product_category, value=Primary Antibodies
Key=research_category, value=Apoptosis, Cancer, Cell Biology, Cell Death, Co-Activators/Co-Repressors, Epigenetics and Nuclear Signaling, Invasion/Microenvironment, Nuclear Receptors, Nuclear Signaling Pathways, Nucleus
Key=clonality, value=Polyclonal
Key=swatch_image, value=/e/k/ek1402_1.png
Key=rating_value, value=98.9
Key=review_count, value=12
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Key=cj_related_products, value=Atherosclerosis:FEK0370^Schizophrenia:A14829^Vascular Diseases:A00557-2|EK1646|A02851|A02851-1
Key=description, value=Boster Bio Anti-NUR77/NR4A1 Antibody Picoband® catalog # PB9766. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=short_description, value=Boster Bio Anti-NUR77/NR4A1 Antibody Picoband® catalog # PB9766. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=meta_keyword, value=Anti-NUR77/NR4A1 Antibody Picoband®
Key=contents, value=Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Key=background, value=NR4A1 (NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1), also called NAK1, GFRP1, TR3, NUR77 or NGFIB, is a protein that in humans is encoded by the NR4A1 gene, which is also a member of the Nur nuclear receptor family of intracellular transcription factors. The NR4A1 gene is mapped on 12q13.13. NR4A1 is involved in cell cycle mediation, inflammation and apoptosis. It plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the NR4A1 protein appears to play a key role in the survival and death of cells. Nr4a1 is overexpressed in Wnt1 -transformed mouse mammary cells. Nr4a1 is also induced by lithium, a Wnt1 mimic, and the Nr4a1 promoter is activated by lithium and beta-catenin, a Wnt1 downstream effector. In contrast, human NR4A1 is not upregulated by beta-catenin, indicating that this gene is regulated differently in human and mouse cells. Adenoviral expression of Nr4a1 induces genes involved in gluconeogenesis, stimulates glucose production both in vitro and in vivo, and raises blood glucose levels.
Key=gene_name, value=NR4A1
Key=synonyms, value=Nuclear receptor subfamily 4 group A member 1;Early response protein NAK1;Nuclear hormone receptor NUR/77;Nur77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3;NR4A1;GFRP1, HMR, NAK1;
Key=application_details, value=Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Key=subcellular_localization, value= Cytoplasm. Nucleus.
Key=tissue_specificity, value= Fetal muscle and adult liver, brain and thyroid.
Key=protein_function, value= Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. .
Key=application_notes, value=Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Key=competitor_equivalent_skus, value=sc 16991|sc 16991 R|sc 16992|sc 16992 R|sc 365113|sc 365113 X|sc 5569|sc 5569 X|sc 7013|sc 7013 X|sc 7014|sc 7014 X|sc 81344|sc 990|sc 990 X
Key=immunogen, value=A synthetic peptide corresponding to a sequence at the C-terminus of human NUR77, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Key=purification, value=Immunogen affinity purified.
Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Key=custom_attribute_1, value=67 kDa
Key=custom_attribute_2, value=WB: Rat Brain Tissue, Mouse Brain Tissue, U87 Whole Cell, HELA Whole Cell
Key=custom_attribute_3, value=PB0818
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Anti-NUR77/NR4A1 Antibody Picoband®

NGFI-B alpha/Nur77/NR4A1 antibody

Boster Bio Anti-NUR77/NR4A1 Antibody Picoband® catalog # PB9766. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance. Cited in 1 publication(s).

Product Info Summary

SKU: PB9766
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: WB

Product Name

Anti-NUR77/NR4A1 Antibody Picoband®

View all NGFI-B alpha/Nur77/NR4A1 Antibodies

SKU/Catalog Number

PB9766

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-NUR77/NR4A1 Antibody Picoband® catalog # PB9766. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-NUR77/NR4A1 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9766)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human NUR77, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

PB9766 is reactive to NR4A1 in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

67 kDa

Calculated molecular weight

64463 MW

Background of NGFI-B alpha/Nur77/NR4A1

NR4A1 (NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1), also called NAK1, GFRP1, TR3, NUR77 or NGFIB, is a protein that in humans is encoded by the NR4A1 gene, which is also a member of the Nur nuclear receptor family of intracellular transcription factors. The NR4A1 gene is mapped on 12q13.13. NR4A1 is involved in cell cycle mediation, inflammation and apoptosis. It plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the NR4A1 protein appears to play a key role in the survival and death of cells. Nr4a1 is overexpressed in Wnt1 -transformed mouse mammary cells. Nr4a1 is also induced by lithium, a Wnt1 mimic, and the Nr4a1 promoter is activated by lithium and beta-catenin, a Wnt1 downstream effector. In contrast, human NR4A1 is not upregulated by beta-catenin, indicating that this gene is regulated differently in human and mouse cells. Adenoviral expression of Nr4a1 induces genes involved in gluconeogenesis, stimulates glucose production both in vitro and in vivo, and raises blood glucose levels.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

View more details

Applications

PB9766 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Positive Control

WB: Rat Brain Tissue, Mouse Brain Tissue, U87 Whole Cell, HELA Whole Cell

Validation Images & Assay Conditions

Gene/Protein Information For NR4A1 (Source: Uniprot.org, NCBI)

Gene Name

NR4A1

Full Name

Nuclear receptor subfamily 4 group A member 1

Weight

64463 MW

Superfamily

nuclear hormone receptor family

Alternative Names

Nuclear receptor subfamily 4 group A member 1;Early response protein NAK1;Nuclear hormone receptor NUR/77;Nur77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3;NR4A1;GFRP1, HMR, NAK1; NR4A1 GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3 nuclear receptor subfamily 4 group A member 1 nuclear receptor subfamily 4 group A member 1|ST-59|TR3 orphan receptor|early response protein NAK1|growth factor-inducible nuclear protein N10|hormone receptor|nerve growth factor IB nuclear receptor variant 1|nuclear hormone receptor NUR/77|orphan nuclear receptor HMR|orphan nuclear receptor TR3|steroid receptor TR3|testicular receptor 3

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on NR4A1, check out the NR4A1 Infographic

NR4A1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for NR4A1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PB9766 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair

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1 Customer Q&As for Anti-NUR77/NR4A1 Antibody Picoband®

Question

We are currently using anti-NUR77/NR4A1 antibody PB9766 for mouse tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it true that the antibody can work on pig tissues as well?

Verified Customer

Verified customer

Asked: 2019-11-25

Answer

The anti-NUR77/NR4A1 antibody (PB9766) has not been tested for cross reactivity specifically with pig tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in pig you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-11-25

Order DetailsPrice
PB9766

100μg

$370
PB9766-10ug

10μg sample (liquid)

$99
PB9766-Biotin

100 μg Biotin conjugated

$570
PB9766-Cy3

100 μg Cy3 conjugated

$570
PB9766-Dylight488

100 μg Dylight488 conjugated

$570
PB9766-Dylight550

100 μg Dylight550 conjugated

$570
PB9766-Dylight594

100 μg Dylight594 conjugated

$570
PB9766-FITC

100 μg FITC conjugated

$570
PB9766-HRP

100 μg HRP conjugated

$570
PB9766-APC

100 μg APC conjugated

$670
PB9766-PE

100 μg PE conjugated

$670
PB9766-iFluor647

100 μg iFluor647 conjugated

$670
PB9766-carrier-free

Carrier Free

$370

More conjugates/formats

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PB9766
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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