Anti-NRG2 Antibody Picoband®

Product Name

Anti-NRG2 Antibody Picoband®

View all Neuregulin-2 Antibodies

SKU/Catalog Number

PA1637

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-NRG2 Antibody catalog # PA1637. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-NRG2 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1637)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human NRG2, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1637 is reactive to NRG2 in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

91 kDa

Calculated molecular weight

91679 MW

Background of Neuregulin-2

Neuregulin 2, also known as NRG2, DON1 or NTAK, is a protein that in humans is encoded by the NRG2 gene. Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. The NRG2 gene is mapped to 5q31.2. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The human NRG2 gene contains 12 exons and the mouse Nrg2 gene contains 12 exons and spans about 180 kb. The NRG2 genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. In particular, the neuregulin-ERBB signaling pathways play crucial roles in regulating the proliferation and differentiation of Schwann cells, the myelin-forming cells in the peripheral nervous system.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1637 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Positive Control

WB: Rat Liver Tissue, COLO320 Whole Cell, SMMC Whole Cell, SW620 Whole Cell

Validation Images & Assay Conditions

Gene/Protein Information For NRG2 (Source: Uniprot.org, NCBI)

Alternative Names

Pro-neuregulin-2, membrane-bound isoform;Pro-NRG2;Neuregulin-2;NRG-2;Divergent of neuregulin-1;DON-1;Neural- and thymus-derived activator for ERBB kinases;NTAK;NRG2;NTAK; NRG2 DON1, HRG2, NTAK neuregulin 2 pro-neuregulin-2, membrane-bound isoform|divergent of neuregulin-1|neural- and thymus-derived activator for ErbB kinases|pro-NRG2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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