NRG2 Antibodies

AND NRG2 ELISA kits, NRG2 Proteins

Many biological assays use antibodies to detect NRG2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NRG2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NRG2 antibodies...

We validate the specificity of these antibodies to NRG2 by testing them on tissues known to express NRG2 positively and negatively. Browse below to find the NRG2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CCN4 Next: RAB3D

NRG2 Infographic by Boster Bio

All NRG2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-NRG2 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

$370
Cat # PA1637
100 μg/vial

Anti-Neuregulin-2 NRG2 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A08302
100ul

NRG2 (NM_013982) Human Over-expression Lysate

Human

$960
Cat # LS009542
100 µg

NRG2 Overview

Facts about Pro-neuregulin-2, membrane-bound isoform.

NRG2 3D structure. Source: alphafold

Pro-neuregulin-2, membrane-bound isoform (NRG2)

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.

May also promote the heterodimerization with the EGF receptor. .

Gene Information

Human
Gene Name:	NRG2
Uniprot:	O14511
Entrez:	9542

Family

Belongs to:

neuregulin family

Alternative Names

divergent of neuregulin-1; DON1; Don-1; HRG2; neuregulin 2; NTAKneural- and thymus-derived activator for ErbB kinases; pro-neuregulin-2, membrane-bound isoform; pro-NRG2

Molecular Weight

Mass (kDA):
91.679 kDA

Genomic Context


Human

Location:	5q31.2
Sequence:	5; NC_000005.10 (139846779..140043675, complement)

Tissue Specificity

Restricted to the cerebellum in the adult.

Subcellular Localizations

[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Does not seem to be active.; [Neuregulin-2]: Secreted.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Nervousness
Schizophrenia
Carcinoma
Congenital Abnormality
Muscle Hypotonia
Heart Diseases
Carcinogenesis
Congenital Heart Defects

Neuroblastoma
Developmental Delay (disorder)
Tissue Adhesions
Myasthenias
Neoplasm Metastasis
Spinal Cord Injuries
Glaucoma, Open-angle

Pathways

Cell Growth
Pathogenesis
Invasive Growth
Brain Development
Myelination
Cell Proliferation
Biofilm Formation
Cell Death
Transport
Cell Adhesion
Cell Migration
Mammary Gland Morphogenesis
Neurogenesis

Heart Formation
Cell Cycle
Cell Differentiation
Glial Cell Growth
Mammary Placode Formation
Nitrate Transport
Gland Morphogenesis

PTMs

Phosphorylation
Cleavage

Nitration
Glycosylation

Ubiquitination

Research Areas

Apoptosis
Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NRG2

References

PMID: 9348101 by Higashiyama S., et al. A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4.

PMID: 9199335 by Busfield S.J., et al. Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus.