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Product Info Summary
| SKU: | A01045 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-Norrin NDP Antibody
View all Norrin/NDP Antibodies
SKU/Catalog Number
A01045
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Norrin NDP Antibody (Catalog # A01045). Tested in ELISA, WB, ICC applications. This antibody reacts with Human.
Storage & Handling
Norrin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Norrin NDP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01045)
Host
Rabbit
Contents
Norrin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Norrin antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human Norrin. The immunogen is located within the first 50 amino acids of Norrin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of FOXA2 are known to exist; this antibody will detect both isoforms. FOXA2 antibody is predicted to not cross-react with other members of the FOXA protein family.
Reactive Species
A01045 is reactive to NDP in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
15044 MW
Background of Norrin/NDP
Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/beta-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina; transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/beta-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01045 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Norrin antibody can be used for detection of Norrin by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Norrin in Jurkat cell lysate with Norrin antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of Norrin in Jurkat cells with Norrin antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For NDP (Source: Uniprot.org, NCBI)
Gene Name
NDP
Full Name
Norrin
Weight
15044 MW
Alternative Names
ND, EVR2, FEVR, Norrin, Norrie disease protein NDP EVR2, FEVR, ND norrin cystine knot growth factor NDP norrin|NDP, norrin cystine knot growth factor|Norrie disease (pseudoglioma)|X-linked exudative vitreoretinopathy 2 protein|norrie disease protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NDP, check out the NDP Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NDP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Norrin NDP Antibody (A01045)
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