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Product Info Summary
| SKU: | A09941 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-NEUCRIN DRAXIN Antibody
View all Draxin/C1orf187 Antibodies
SKU/Catalog Number
A09941
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NEUCRIN DRAXIN Antibody (Catalog # A09941). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
NEUCRIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-NEUCRIN DRAXIN Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09941)
Host
Rabbit
Contents
NEUCRIN Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Neucrin antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Neucrin. The immunogen is located within the last 50 amino acids of NEUCRIN.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP.
Reactive Species
A09941 is reactive to DRAXIN in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
38650 MW
Background of Draxin/C1orf187
Neucrin, also known as Draxin, is a repulsive guidance protein for the spinal cord and forebrain commissures. It is thought to act as an antagonist of canonical Wnt signaling by inhibiting the stabilization of cytosolic beta-catenin. Ectopically expressed neucrin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo while Neucrin-null mice showed defasciculation of spinal cord commissural axons and an absence of all forebrain commisures. Other experiments in mice have shown that olfactory bulb axonal outgrowth is inhibited by Neucrin, suggesting that Neucrin functions as an inhibitory guidance cue for olfactory bulb axons.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09941 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Neucrin antibody can be used for detection of Neucrin by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Neucrin in rat cerebellum tissue lysate with Neucrin antibody at 1 μg/mL.
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Immunohistochemistry of NEUCRIN in mouse brain tissue with NEUCRIN antibody at 5 μg/mL.
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Immunofluorescence of NEUCRIN in mouse brain tissue with NEUCRIN antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For DRAXIN (Source: Uniprot.org, NCBI)
Gene Name
DRAXIN
Full Name
Draxin
Weight
38650 MW
Superfamily
draxin family
Alternative Names
UNQ3119, neucrin, AGPA3119, C1orf187, PSEC0258, UNQ3119/PRO10268, Draxin, Dorsal inhibitory axon guidance protein Draxin|2610109H07Rik, Neu, neucrin|dorsal inhibitory axon guidance protein|draxin|dorsal repulsive axon guidance protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DRAXIN, check out the DRAXIN Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DRAXIN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NEUCRIN DRAXIN Antibody (A09941)
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