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Product Info Summary
| SKU: | A07276-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-Nanos homolog 1 Nanos1 Antibody
SKU/Catalog Number
A07276-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Nanos homolog 1 Nanos1 Antibody (Catalog # A07276-1). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Nanos1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Nanos homolog 1 Nanos1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07276-1)
Host
Rabbit
Contents
Nanos1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Nanos1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human Nanos1. The immunogen is located within amino acids 160 - 210 of Nanos1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Anti-UEV1A may also recognize other isoforms of UEV1A.
Reactive Species
A07276-1 is reactive to NANOS1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
30230 MW
Background of Nanos1
Nanos1 is one of three known mammalian homologs to the Drosophila gene nanos. Nanos1 is an RNA-binding protein containing a zinc-finger motif and is expressed in the developing nervous system and continues in the adult brain. Interestingly, unlike mice deficient in either nanos2 or nanos3, mice lacking the nanos1 gene develop normally with no sign of abnormalities. Recently it has been found that expression of nanos1 mRNA is down-regulated by E-cadherin in a human breast cancer cell line and the amino-terminal domain on Nanos1 interacts with the E-cadherin-binding protein p120ctn. Furthermore, overexpression of Nanos1 in human colorectal DLD1 cancer cells functionally abolished cell-cell adhesion, allowing the cancer cells to develop strong migratory and invasive properties. These results suggest that targeting Nanos1 might prove an effective strategy in the treatment of E-cadherin-negative tumors.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07276-1 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Nanos1 antibody can be used for detection of Nanos1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Nanos1 in rat brain tissue lysate with Nanos1 antibody at (A) 1 and (B) 2 μg/mL.
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Immunofluorescence of nanos1 in human brain tissue with nanos1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For NANOS1 (Source: Uniprot.org, NCBI)
Gene Name
NANOS1
Full Name
Nanos homolog 1
Weight
30230 MW
Superfamily
nanos family
Alternative Names
NOS1, SPGF12, NOS1, Nanos homolog 1, NOS-1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NANOS1, check out the NANOS1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NANOS1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Nanos homolog 1 Nanos1 Antibody (A07276-1)
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