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Product Info Summary
| SKU: | A08138 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-NALP5 NLRP5 Antibody
SKU/Catalog Number
A08138
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NALP5 NLRP5 Antibody (Catalog # A08138). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
NALP5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-NALP5 NLRP5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08138)
Host
Rabbit
Contents
NALP5 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
NALP5 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human NALP5. The immunogen is located within the last 50 amino acids of NALP5.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody will not cross-react with JMJD1A or JMJD1C.
Reactive Species
A08138 is reactive to NLRP5 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
134342 MW
Background of Nlrp5
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08138 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
NALP5 antibody can be used for detection of NALP5 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of NALP5 in human brain tissue with NALP5 antibody at 10 μg/mL.
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Immunofluorescence of NALP5 in human brain tissue with NALP5 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For NLRP5 (Source: Uniprot.org, NCBI)
Gene Name
NLRP5
Full Name
NACHT, LRR and PYD domains-containing protein 5
Weight
134342 MW
Alternative Names
MATER, NALP5, PAN11, PYPAF8, CLR19.8, MATER, NACHT, LRR and PYD domains-containing protein 5, Mater protein homolog Nlrp5|Mat, Mater, N, Nalp5, O, Op1, PAN11|NLR family, pyrin domain containing 5|NACHT, LRR and PYD domains-containing protein 5|NACHT, leucine rich repeat and PYD containing 5|maternal that embryos require|ooplasm-specific protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NLRP5, check out the NLRP5 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NLRP5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NALP5 NLRP5 Antibody (A08138)
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