Anti-MUC6 (Mucin 6 / Gastric Mucin) Monoclonal Antibody

Product Name

Anti-MUC6 (Mucin 6 / Gastric Mucin) Monoclonal Antibody

View all MUC6 Antibodies

SKU/Catalog Number

M02143

Size

100ug/vial

Form

Liquid

Description

Boster Bio Anti-MUC6 (Mucin 6 / Gastric Mucin) Monoclonal Antibody (Catalog # M02143). Tested in IHC applications. This antibody reacts with Human.

Storage & Handling

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Cite This Product

Anti-MUC6 (Mucin 6 / Gastric Mucin) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02143)

Host

Mouse

Contents

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Clonality

Monoclonal

Clone Number

Clone: MUC6/916

Isotype

IgG1, kappa

Immunogen

Recombinant fragment covering tandem repeats of human MUC6 protein (exact sequence is proprietary)

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Does not cross-react with primate, avian or amphibian GR.

Reactive Species

M02143 is reactive to MUC6 in Human

Applications

M02143 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

257051 MW

Background of MUC6

The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconstitution

Reconstitute with distilled water.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Validation Images & Assay Conditions

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Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with Anti-MUC6 Monoclonal Antibody (MUC6/916).

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Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with Anti-MUC6 Monoclonal Antibody (MUC6/916).

Gene/Protein Information For MUC6 (Source: Uniprot.org, NCBI)

Alternative Names

gastric mucin; Gastric mucin-6; MUC-6; mucin 6, gastric; mucin 6, oligomeric mucus/gel-forming; mucin-6 MUC6 MUC-6 mucin 6, oligomeric mucus/gel-forming mucin-6|gastric mucin-6

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In this infographic, you will see the following information for MUC6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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