Anti-MOL1A MOB1B Antibody

Product Name

Anti-MOL1A MOB1B Antibody

View all MOB4A Antibodies

SKU/Catalog Number

A09405

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-MOL1A MOB1B Antibody (Catalog # A09405). Tested in WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-MOL1A MOB1B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09405)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human MOL1A.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A09405 is reactive to Mob1b in Human, Mouse

Applications

A09405 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

25091 MW

Background of MOB4A

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Devroe E., J. Biol. Chem. 279:24444-24451(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

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Western blot analysis of extracts from 293 cells, COS-7 cells and HUVEC cells all treated with IFN (2500U/ml, 30mins), using MOL1A antibody A09405.

Gene/Protein Information For Mob1b (Source: Uniprot.org, NCBI)

Alternative Names

MATS2; MGC33910; Mob1 homolog 1A; MOB1, Mps One Binder kinase activator-like 1A (yeast); Mob1A; Mob1Bmps one binder kinase activator-like 1A; MOB4Amob1A; Protein Mob4A Mob1b|1110003E08Rik, AU015450, B230364F10, Mobk, Mobkl1a|MOB kinase activator 1B|MOB kinase activator 1B|MOB1, Mps One Binder kinase activator-like 1A|mob1 homolog 1A|mps one binder kinase activator-like 1A

For more info on Mob1b, check out the Mob1b Infographic

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In this infographic, you will see the following information for Mob1b: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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