Anti-Menin/MEN1 Antibody Picoband®

Product Name

Anti-Menin/MEN1 Antibody Picoband®

View all Menin Antibodies

SKU/Catalog Number

PB9263

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Menin/MEN1 Antibody Picoband® catalog # PB9263. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Menin/MEN1 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9263)

Host

Rabbit

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.01 mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human Menin recombinant protein (Position: P301-L615). Human Menin shares 93% and 94% amino acid (aa) sequence identity with mouse and rat Menin, respectively.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9263 is reactive to MEN1 in Human, Mouse

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

68 kDa

Calculated molecular weight

68023 MW

Background of Menin

The MEN1 gene encodes menin, a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling. It is mapped to 11q13.1. MEN1 is considered to act as a tumor suppressor gene. It has been found that that MEN1 inactivation by antisense RNA antagonizes transforming growth factor-beta-mediated cell growth inhibition. Overexpression of MEN1 in an inducible cell culture system downregulated the proximal promoter. In vitro studies have shown that MEN1 is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. What’s more, MEN1 was essential to maintain MLL-associated myeloid transformation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PB9263 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Mouse

Positive Control

WB: HELA Whole Cell, 293T Whole Cell, SMMC Whole Cell, HEPA Whole Cell, COLO320 Whole Cell

Validation Images & Assay Conditions

Gene/Protein Information For MEN1 (Source: Uniprot.org, NCBI)

Alternative Names

Menin;MEN1;SCG2; MEN1 MEAI, SCG2 menin 1 menin

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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