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- Table of Contents
Facts about Menin.
Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity.
Human | |
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Gene Name: | MEN1 |
Uniprot: | O00255 |
Entrez: | 4221 |
Belongs to: |
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No superfamily |
MEAI; MEN1; Menin; multiple endocrine neoplasia I; multiple
Mass (kDA):
68.023 kDA
Human | |
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Location: | 11q13.1 |
Sequence: | 11; NC_000011.10 (64803514..64811294, complement) |
Ubiquitous.
Nucleus. Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
PMID: 9103196 by Chandrasekharappa S.C., et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1.
PMID: 17555499 by Toledo R.A., et al. Novel MEN1 germline mutations in Brazilian families with multiple endocrine neoplasia type 1.