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Product Info Summary
| SKU: | A08189 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-MECR Antibody
SKU/Catalog Number
A08189
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-MECR Antibody (Catalog # A08189). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
MECR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-MECR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08189)
Host
Rabbit
Contents
MECR Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rabbit polyclonal MECR antibody was raised against a 15 amino acid peptide near the carboxy terminus of human MECR. The immunogen is located within amino acids 300 - 350 of MECR.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of MECR are known to exist; this antibody will detect both isoforms.
Reactive Species
A08189 is reactive to MECR in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
40462 MW
Background of Mecr
The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08189 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
MECR antibody can be used for detection of MECR by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human, mouse, and rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of MECR in human brain tissue lysate with MECR antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of MECR in (A) human brain tissue
Protein Target Info & Infographic
Gene/Protein Information For MECR (Source: Uniprot.org, NCBI)
Gene Name
MECR
Full Name
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Weight
40462 MW
Superfamily
zinc-containing alcohol dehydrogenase family
Alternative Names
NRBF1, CGI-63, FASN2B, NBRF1, Trans-2-enoyl-CoA reductase, mitochondrial, Nuclear receptor-binding factor 1, HsNrbf-1 Mecr|AI195831, NRBF-1, Nrb, Nrbf1|mitochondrial trans-2-enoyl-CoA reductase|enoyl-[acyl-carrier-protein] reductase, mitochondrial|2-enoyl thioester reductase|nuclear receptor binding factor 1|trans-2-enoyl-CoA reductase, mitochondrial
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MECR, check out the MECR Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MECR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-MECR Antibody (A08189)
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