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Product Info Summary
| SKU: | A07328-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-MD-1 LY86 Antibody
SKU/Catalog Number
A07328-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-MD-1 LY86 Antibody (Catalog # A07328-1). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
MD-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-MD-1 LY86 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07328-1)
Host
Rabbit
Contents
MD-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
MD-1 antibody was raised against a 15 amino acid synthetic peptide from near the center of human MD-1. The immunogen is located within the last 50 amino acids of MD-1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.
Reactive Species
A07328-1 is reactive to LY86 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
17906 MW
Background of MD-1/LY86
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07328-1 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
MD-1 antibody can be used for the detection of MD-1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of MD-1 in human spleen tissue with MD-1 antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LY86 (Source: Uniprot.org, NCBI)
Gene Name
LY86
Full Name
Lymphocyte antigen 86
Weight
17906 MW
Alternative Names
MD-1, MMD-1, dJ80N2.1, MD1, Lymphocyte antigen 86, Protein MD-1, Ly-86 LY86 MD-1, MD1, MMD-1, dJ80N2.1 lymphocyte 86 lymphocyte 86|MD-1, RP105-associated|ly-86|protein MD-1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LY86, check out the LY86 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LY86: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-MD-1 LY86 Antibody (A07328-1)
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