MBD1 Antibodies

AND MBD1 ELISA kits, MBD1 Proteins

Many biological assays use antibodies to detect MBD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MBD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MBD1 antibodies...

We validate the specificity of these antibodies to MBD1 by testing them on tissues known to express MBD1 positively and negatively. Browse below to find the MBD1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MBD1 Infographic by Boster Bio

All MBD1 Products

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Product

Figures

Specificity

Applications

Price

Anti-MBD1 Monoclonal Antibody

3 Q&As

Human

IP, IF, IHC, ICC, WB

$370
Cat # M02336
100 μl

Anti-MBD1 Antibody Picoband®

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # A02336-1
100 μg/vial

MBD1 (NM_015846) Human Over-expression Lysate

Human

$960
Cat # LS004152
100 µg

MBD1 Overview

Facts about Methyl-CpG-binding domain protein 1.

MBD1 3D structure. Source: alphafold

Methyl-CpG-binding domain protein 1 (MBD1)

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that's made by DNA damage by methylmethanesulfonate (MMS).

Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which subsequently recruits factors like the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone'Lys-9' trimethylation.

Gene Information

Human
Gene Name:	MBD1
Uniprot:	Q9UIS9
Entrez:	4152

Family

Belongs to:

No superfamily

Alternative Names

CXXC-type zinc finger protein 3; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG binding domain protein 1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1CXXC3RFT; Protein containing methyl-CpG-binding domain 1; the regulator of fibroblast growth factor 2 (FGF-2) transcription

Molecular Weight

Mass (kDA):
66.607 kDA

Genomic Context


Human

Location:	18q21.1
Sequence:	18; NC_000018.10 (50266882..50281774, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus. Nucleus matrix. Nucleus speckle. Chromosome. Colocalizes with the Ten-1 ICD form of TENM1 in foci associated with the nuclear matrix (By similarity). Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes.