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Product Info Summary
| SKU: | A04567 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | WB |
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Product info
Product Name
Anti-MASTL Antibody
SKU/Catalog Number
A04567
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-MASTL Antibody (Catalog # A04567). Tested in WB applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-MASTL Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04567)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from C-terminal of human MASTL.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A04567 is reactive to MASTL in Human
Reconstitution
Calculated molecular weight
97319 MW
Background of Mastl
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
Ota T., Nat. Genet. 36:40-45(2004).
Deloukas P., Nature 429:375-381(2004).
Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04567 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Validation Images & Assay Conditions
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Western blot analysis of extracts from HeLa cells, using MASTL antibody A04567.
Protein Target Info & Infographic
Gene/Protein Information For MASTL (Source: Uniprot.org, NCBI)
Gene Name
MASTL
Full Name
Serine/threonine-protein kinase greatwall
Weight
97319 MW
Superfamily
protein kinase superfamily
Alternative Names
Serine/threonine-protein kinase greatwall;GW;GWL;hGWL;2.7.11.1;Microtubule-associated serine/threonine-protein kinase-like;MAST-L;MASTL;GW, GWL, THC2; Mastl|2700091H24Rik, C88295, GW, GWL, MAST-L, THC2|microtubule associated serine/threonine kinase-like|serine/threonine-protein kinase greatwall|microtubule-associated serine/threonine-protein kinase-like
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MASTL, check out the MASTL Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MASTL: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-MASTL Antibody (A04567)
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No publications found for A04567
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