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Product Info Summary
| SKU: | A11290 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-LRRTM3 Antibody
SKU/Catalog Number
A11290
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LRRTM3 Antibody (Catalog # A11290). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
LRRTM3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LRRTM3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11290)
Host
Rabbit
Contents
LRRTM3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LRRTM3 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human LRRTM3. The immunogen is located within the last 50 amino acids of LRRTM3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of LRRTM3 are known to exist; this antibody will only detect the larger isoform.
Reactive Species
A11290 is reactive to LRRTM3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
65896 MW
Background of Lrrtm3
The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11290 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LRRTM3 antibody can be used for detection of LRRTM3 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LRRTM3 in mouse brain tissue lysate with LRRTM3 antibody at 0.5 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of LRRTM3 in human brain tissue with LRRTM3 antibody at 2.5 μg/mL
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Immunofluorescence of LRRTM3 in human brain tissue with LRRTM3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LRRTM3 (Source: Uniprot.org, NCBI)
Gene Name
LRRTM3
Full Name
Leucine-rich repeat transmembrane neuronal protein 3
Weight
65896 MW
Superfamily
LRRTM family
Alternative Names
Leucine-rich repeat transmembrane neuronal protein 3 Lrrtm3|9630044H04Rik|leucine rich repeat transmembrane neuronal 3|leucine-rich repeat transmembrane neuronal protein 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LRRTM3, check out the LRRTM3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LRRTM3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LRRTM3 Antibody (A11290)
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