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Product Info Summary
| SKU: | A03517 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-LRRC8A Antibody
SKU/Catalog Number
A03517
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LRRC8A Antibody (Catalog # A03517). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
LRRC8A antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-LRRC8A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03517)
Host
Rabbit
Contents
LRRC8A antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LRRC8A antibody was raised against a 15 amino acid peptide near the amino terminus of human LRRC8A. The immunogen is located within amino acids 60 - 110 of LRRC8A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
LRRC8A antibody is human, mouse and rat reactive.
Reactive Species
A03517 is reactive to LRRC8A in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
94199 MW
Background of LRRC8A
The leucine rich repeat containing 8 family member A protein (LRRC8A) belongs the LRRC8 family of proteins within the LRR superfamily of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions (1,2). LRRC8A is a four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation (1). LRRC8A has also been shown to be an essential component of the volume-regulated anion channel VRAC (3).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03517 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LRRC8A antibody can be used for detection of LRRC8A by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LRRC8A in EL4 cell lysate with LRRC8A antibody at (A) 1 and (B) 2 μg/ml.
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Immunohistochemistry of LRRC8A in rat spleen tissue with LRRC8A antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LRRC8A (Source: Uniprot.org, NCBI)
Gene Name
LRRC8A
Full Name
Volume-regulated anion channel subunit LRRC8A
Weight
94199 MW
Superfamily
LRRC8 family
Alternative Names
Leucine rich repeat containing 8 family member A, leucine-rich repeat-containing protein 8A, LRRC8, AGM5 LRRC8A AGM5, LRRC8, SWELL1 leucine rich repeat containing 8 VRAC subunit A volume-regulated anion channel subunit LRRC8A|leucine rich repeat containing 8 family member A|leucine-rich repeat-containing protein 8A|swelling protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LRRC8A, check out the LRRC8A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LRRC8A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LRRC8A Antibody (A03517)
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