LRRC8A Antibodies

AND LRRC8A ELISA kits, LRRC8A Proteins

Many biological assays use antibodies to detect LRRC8A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRRC8A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRRC8A antibodies...

We validate the specificity of these antibodies to LRRC8A by testing them on tissues known to express LRRC8A positively and negatively. Browse below to find the LRRC8A antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LRRC8A Infographic by Boster Bio

All LRRC8A Products

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Specificity

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Anti-LRRC8A Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$449
Cat # A03517
0.1 mg

LRRC8A (NM_019594) Human Recombinant Protein

$1062
Cat # PROTQ8IWT6
20 µg

LRRC8A Overview

Facts about Volume-regulated anion channel subunit LRRC8A.

LRRC8A 3D structure. Source: alphafold

Volume-regulated anion channel subunit LRRC8A (LRRC8A)

Essential part of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:29769723). The VRAC station conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731).

Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471).

Gene Information

Human
Gene Name:	LRRC8A
Uniprot:	Q8IWT6
Entrez:	56262

Family

Belongs to:

LRRC8 family

Alternative Names

AGM5; FLJ10337; FLJ41617; KIAA1437; KIAA1437leucine rich repeat containing 8; leucine rich repeat containing 8 family, member A; leucine-rich repeat-containing protein 8A; LRRC8; LRRC8A; SWELL1

Molecular Weight

Mass (kDA):
94.199 kDA

Genomic Context


Human

Location:	9q34.11
Sequence:	9; NC_000009.12 (128882133..128918042)

Tissue Specificity

Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells. Expressed on T-cells as well as on B-lineage cells.