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Product Info Summary
| SKU: | A00217 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-LKB1 STK11 Antibody
View all LKB1/STK11 Antibodies
SKU/Catalog Number
A00217
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LKB1 STK11 Antibody (Catalog # A00217). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
LKB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LKB1 STK11 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00217)
Host
Rabbit
Contents
LKB1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LKB1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human LKB1. The immunogen is located within amino acids 310 - 360 of LKB1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of IL-15 are known to exist.
Reactive Species
A00217 is reactive to STK11 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
48636 MW
Background of LKB1/STK11
The LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK). Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00217 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LKB1 antibody can be used for detection of LKB1 by Western blot at 1 μg/mL. LKB1 often migrates at a higher than expected molecular weight in SDS-PAGE.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LKB1 in PC-3 cell lysate with LKB1 antibody at 1 μg/mL in the (A) absence or (B) presence of blocking peptide.
Protein Target Info & Infographic
Gene/Protein Information For STK11 (Source: Uniprot.org, NCBI)
Gene Name
STK11
Full Name
Serine/threonine-protein kinase STK11
Weight
48636 MW
Superfamily
protein kinase superfamily
Alternative Names
PJS, LKB1, hLKB1, PJS, Liver kinase B1 STK11 LKB1, PJS, hLKB1 serine/threonine kinase 11 serine/threonine-protein kinase STK11|liver kinase B1|polarization-related protein LKB1|renal carcinoma NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on STK11, check out the STK11 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for STK11: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LKB1 STK11 Antibody (A00217)
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