Anti-LASS6 CERS6 Antibody

Product Name

Anti-LASS6 CERS6 Antibody

View all LASS6 Antibodies

SKU/Catalog Number

A07033

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-LASS6 CERS6 Antibody (Catalog # A07033). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

LASS6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-LASS6 CERS6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07033)

Host

Rabbit

Contents

LASS6 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

LASS6 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human LASS6. The immunogen is located within the last 50 amino acids of LASS6.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least two isoforms of LASS6 are known to exist. This antibody is predicted not to cross-react with LASS5.

Reactive Species

A07033 is reactive to CERS6 in Human, Mouse, Rat

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

44890 MW

Background of LASS6

The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. Like the highly homologous LASS5, LASS6 is also an endoplasmic reticulum, multi-pass membrane protein. LASS6 is also involved in the synthesis of C14, C16 and C18-ceramide, but shows a preference for unsaturated fatty acids. LASS6 is broadly expressed in a wide range of tissues and microarray data suggests that it may play a role in cancer differentiation and early embryonic development.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A07033 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

LASS6 antibody can be used for detection of LASS6 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For CERS6 (Source: Uniprot.org, NCBI)

Alternative Names

CERS5, LASS6, Ceramide synthase 6, LAG1 longevity assurance homolog 6, CerS6 Cers6|4732462C07Rik, AW544719, Cer, L, Lass6, T1, T1L|ceramide synthase 6|ceramide synthase 6|LAG1 homolog, ceramide synthase 6|LAG1 longevity assurance homolog 6|longevity assurance homolog 6

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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