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Product Info Summary
| SKU: | A06290 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-LAMTOR1 Antibody
SKU/Catalog Number
A06290
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LAMTOR1 Antibody (Catalog # A06290). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
LAMTOR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-LAMTOR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06290)
Host
Rabbit
Contents
LAMTOR1 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rabbit polyclonal LAMTOR1 antibody was raised against a 17 amino acid peptide near the amino terminus of human LAMTOR1 . The immunogen is located within the first 50 amino acids of LAMTOR1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
LAMTOR1 antibody is human, mouse and rat specific. LAMTOR1 antibody is predicted to not cross-react with other LAMTOR family proteins.
Reactive Species
A06290 is reactive to LAMTOR1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
17745 MW
Background of LAMTOR1
LAMTOR1 is a 161 amino acid membrane protein belonging to the LAMTOR family. It has been identified to interact with and recruit the four Rag GTPases (Rag A-D) to the surface of lysosomes (1). The mTORC1 kinase complex is a critical component in the regulation of cell growth (2). As part of the ragulator complex, LAMTOR1 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids (3). LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes / lysosomes (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06290 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LAMTOR1 antibody can be used for detection of LAMTOR1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LAMTOR1 in A431 cell lysate with LAMTOR1 antibody at 1 μg/ml.
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Immunohistochemistry of LAMTOR1 in human small intestine tissue with LAMTOR1 antibody at 5 μg/mL.
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Immunofluorescence of LAMTOR1 in human small intestine tissue with LAMTOR1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LAMTOR1 (Source: Uniprot.org, NCBI)
Gene Name
LAMTOR1
Full Name
Ragulator complex protein LAMTOR1
Weight
17745 MW
Superfamily
LAMTOR1 family
Alternative Names
p18, PDRO, C11orf59, p27RF-Rho, Ragulator1, PP7157, Ragulator complex protein LAMTOR1, Lipid raft adaptor protein p18 LAMTOR1 C11orf59, PDRO, Ragulator1, p18, p27RF-Rho late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ragulator complex protein LAMTOR1|RhoA activator C11orf59|late endosomal/lysosomal adaptor and MAPK and MTOR activator 1|lipid raft adaptor protein p18|p27Kip1-releasing factor from RhoA|p27kip1 releasing factor from RhoA|protein associated with DRMs and endosomes|ragulator complex protein PDRO
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LAMTOR1, check out the LAMTOR1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LAMTOR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LAMTOR1 Antibody (A06290)
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