Anti-Kinesin light chain 1 KLC1 Antibody

Product Name

Anti-Kinesin light chain 1 KLC1 Antibody

View all KLC1 Antibodies

SKU/Catalog Number

A04116

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Kinesin light chain 1 KLC1 Antibody catalog # A04116. Tested in WB,IHC,IF applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Kinesin light chain 1 KLC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04116)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human MST-3

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04116 is reactive to KLC1 in Human, Mouse, Rat

Applications

A04116 is guaranteed for IF, IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

65310 MW

Background of KLC1

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Schinkmann K., J. Biol. Chem. 272:28695-28703(1997).
Zhou T.-H., J. Biol. Chem. 275:2513-2519(2000).
Dunham A., Nature 428:522-528(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000
IHC/IF: 1:50-1:200

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For KLC1 (Source: Uniprot.org, NCBI)

Alternative Names

hKLC1B; hKLC1G; hKLC1J; hKLC1S; kinesin 2 60/70kDa; kinesin 2; kinesin light chain 1; KLC 1; KLChKLC1N; KNS2AhKLC1P; KNS2hKLC1R; medulloblastoma antigen MU-MB-2.50; MGC15245 KLC1 KLC, KNS2, KNS2A kinesin light chain 1 kinesin light chain 1|kinesin 2 60/70kDa|medulloblastoma antigen MU-MB-2.50

For more info on KLC1, check out the KLC1 Infographic

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In this infographic, you will see the following information for KLC1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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