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Product Info Summary
| SKU: | A03278-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Thymopoietin TMPO Antibody
View all Thymopoietin/LAP2 Antibodies
SKU/Catalog Number
A03278-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Thymopoietin TMPO Antibody (Catalog # A03278-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
Thymopoietin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Thymopoietin TMPO Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03278-1)
Host
Rabbit
Contents
Thymopoietin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Thymopoietin antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human Thymopoietin. The immunogen is located within amino acids 80 - 130 of Thymopoietin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of Thymopoietin are known to exist; this antibody will detect all isoforms. Thymopoietin antibody is predicted to not cross-react with other LEM domain-containing proteins.
Reactive Species
A03278-1 is reactive to TMPO in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
75492 MW
Background of Thymopoietin/LAP2
Thymopoietin (TMPO), also known as LAP2, is a widely expressed lem-domain-containing nuclear protein that is thought to play an important role in the regulation of nuclear architecture by binding lamin B1 and chromosomes in a manner regulated by phosphorylation during mitosis. Thymopoietin associates with nucleoplasmic lamins A/C, which are encoded by the dilated cardiomyopathy (DCM) gene LMNA; mutations in Thymopoietin disrupt this binding, suggesting that Thymopoietin may be a candidate disease gene for DCM.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03278-1 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Thymopoietin antibody can be used for detection of Thymopoietin by Western blot at 0.25 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Thymopoietin in HeLa cell lysate with Thymopoietin antibody at 0.25 μg/mLl in (A) the absence and (B) the presence of blocking peptide.
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Immunocytochemistry of Thymopoietin in HeLa cells with Thymopoietin antibody at 2.5 μg/mL.
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Immunofluorescence of Thymopoietin in HeLa cells with Thymopoietin antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TMPO (Source: Uniprot.org, NCBI)
Gene Name
TMPO
Full Name
Lamina-associated polypeptide 2, isoform alpha
Weight
75492 MW
Superfamily
LEM family
Alternative Names
TP, LAP2, CMD1T, LEMD4, PRO0868, Lamina-associated polypeptide 2, isoform alpha, Thymopoietin isoform alpha, TP alpha TMPO CMD1T, LAP2, LEMD4, PRO0868, TP thymopoietin thymopoietin|LEM domain containing 4|lamina-associated polypeptide 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TMPO, check out the TMPO Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TMPO: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Thymopoietin TMPO Antibody (A03278-1)
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