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Key=image_label, value=Formalin-fixed, paraffin-embedded human pancreas stained with Anti-Insulin Monoclonal Antibody (IRDN/805).
Key=small_image_label, value=Formalin-fixed, paraffin-embedded human pancreas stained with Anti-Insulin Monoclonal Antibody (IRDN/805).
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Key=description, value=Boster Bio Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Monoclonal Antibody (Catalog # M00067). Tested in IHC applications. This antibody reacts with Human, Cow, Pig, Rabbit, Mouse.
Key=short_description, value=Boster Bio Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Monoclonal Antibody (Catalog # M00067). Tested in IHC applications. This antibody reacts with Human, Cow, Pig, Rabbit, Mouse.
Key=meta_keyword, value=Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Monoclonal Antibody
Key=contents, value=Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Key=background, value=Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
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Key=application_details, value=Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(No special pretreatment is required for staining of formalin/paraffin tissues.)Optimal dilution for a specific application should be determined.
Key=subcellular_localization, value=Cytoplasmic
Key=tissue_specificity, value= Widely expressed. Isoform 3 is not expressed in the pituitary gland. .
Key=protein_function, value= Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Key=application_notes, value=Anti-MEK 2 Biotin Conjugated (MOUSE) Antibody is suitable for use in Western Blotting and ELISA. Specific conditions of reactivity should be optimized by the end user. Expect a band of approximately 44 kDa.
Key=competitor_equivalent_skus, value=sc 8909|sc 58615|sc 10747|sc 20074|sc 8910|sc 376683
Key=immunogen, value=Recombinant INS protein
Key=purification, value=200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Key=storage, value=Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Monoclonal Antibody

INS antibody

Boster Bio Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Monoclonal Antibody (Catalog # M00067). Tested in IHC applications. This antibody reacts with Human, Cow, Pig, Rabbit, Mouse. Cited in 11 publication(s).

Product Info Summary

SKU: M00067
Size: 100ug/vial
Reactive Species: Cow, Human, Mouse, Pig, Rabbit
Host: Mouse
Application: IHC

Product Name

Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Monoclonal Antibody

View all INS Antibodies

SKU/Catalog Number

M00067

Size

100ug/vial

Form

Liquid

Description

Boster Bio Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Monoclonal Antibody (Catalog # M00067). Tested in IHC applications. This antibody reacts with Human, Cow, Pig, Rabbit, Mouse.

Storage & Handling

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Cite This Product

Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00067)

Host

Mouse

Contents

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Clonality

Monoclonal

Clone Number

Clone: IRDN/805

Isotype

IgG1, kappa

Immunogen

Recombinant INS protein

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00067 is reactive to INS in Cow, Human, Mouse, Pig, Rabbit

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 100 µL

Calculated molecular weight

11981 MW

Background of INS

Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

View more details

Applications

M00067 is guaranteed for IHC Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(No special pretreatment is required for staining of formalin/paraffin tissues.)Optimal dilution for a specific application should be determined.

Validation Images & Assay Conditions

Gene/Protein Information For INS (Source: Uniprot.org, NCBI)

Gene Name

INS

Full Name

Insulin

Weight

11981 MW

Superfamily

insulin family

Alternative Names

Insulin;Insulin B chain;Insulin A chain;INS; INS IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, PNDM4 insulin insulin|preproinsulin|proinsulin

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on INS, check out the INS Infographic

INS infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for INS: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

M00067 has been cited in 11 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Cotransplantation With Xenogenetic Neonatal Porcine Sertoli Cells Significantly Prolongs Islet Allograft Survival in Nonimmunosuppressive Rats

Attenuated Tregs increase susceptibility to type 1 diabetes in prenatal nicotine exposed female offspring mice

Liraglutide protects β-cell function by reversing histone modification of Pdx-1 proximal promoter in catch-up growth male rats

Reversible immortalization of rat pancreatic β cells with a novel immortalizing and tamoxifen-mediated self-recombination tricistronic vector

Gao T,Jiao Y,Liu Y,Li T,Wang Z,Wang D.Protective Effects of Konjac and Inulin Extracts on Type 1 and Type 2 Diabetes.J Diabetes Res.2019 Oct 7;2019:3872182.doi:10.1155/2019/3872182.PMID:31687407;PMCID:PMC6800947.
Species: Rat
M00067 usage in article: APP:IHC, SAMPLE: PANCREASE, DILUTION:1:200

Heng Yang,Shuo Wang,Yingchun Ye,Min Xie,Yubin Li,Hong Ji,Jing Li,Ling Gao, GLP-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice, Neuropeptides, 2020,102110,ISSN 0143-4179,https://doi.org/10.1016/j.npep.2
Species: Mouse
M00067 usage in article: APP:IF, SAMPLE:PANCREAS, DILUTION:NA

Gynura divaricata rich in 3, 5%u2212/4, 5-dicaffeoylquinic acid and chlorogenic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic %u2026

RIG-I inhibits pancreatic ? cell proliferation through competitive binding of activated Src

Interference effect of oral administration of mulberry branch bark powder on the incidence of type II diabetes in mice induced by streptozotocin

miR-487b mitigates chronic heart failure through inhibition of the IL-33/ST2 signaling pathway

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Order DetailsPrice
M00067-100ug

100 μg

$486

Free Secondary Antibody

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M00067
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$486.00

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