|Product Name||Anti-Importin-9 Antibody|
|Storage & Handling||Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.|
|Description||Rabbit IgG Polyclonal antibody for IPO9 detection. Tested with IHC, WB in Mouse, Human.|
|Cite This Product||Anti-Importin-9 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10216)|
|Contents/Buffer||100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide.|
|Immunogen||A partial length recombinant Importin-9 protein (amino acids 740-1,041).|
Assay Dilutions Overview
Western blot analysis, 0.25-1.0 μg/ml
Immunohistochemical analysis, 5 μg/ml
Images And Assay Conditions
Immunohistochemical analysis of Importin-9. Anti-Importin-9 antibody (Respiratory Epithelium tissue at 5 μg/ml.
Immunohistochemical analysis of Importin-9. Anti-Importin-9 antibody in human Colon tissue at 5 μg/ml.
Western blot analysis of Importin-9. Anti- Importin-9 antibody was used at 0.25 μg/ml on 1) 293 and 2) 3T3 lysates.
Protein Target Info (Source: Uniprot.org)
|Alternative Names||Importin-9;Imp9;Ran-binding protein 9;RanBP9;IPO9;IMP9, KIAA1192, RANBP9;HSPC273;|
|Subcellular Localization||Cytoplasm . Nucleus .|
|Molecular Weight||115963 MW|
*if product is indicated to react with multiple species, protein info is based on the human gene.
|Protein Function||Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6. .|
|Research Areas||Human, Mouse
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