Anti-IL28RA Antibody (Center)

Product Name

Anti-IL28RA Antibody (Center)

View all IL-28R alpha/IFN-lambda R1 Antibodies

SKU/Catalog Number

M05986

Size

80 µl

Description

Boster Bio Anti-IL28RA Antibody (Center) (Catalog # M05986). Tested in WB application(s). This antibody reacts with Human.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-IL28RA Antibody (Center) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M05986)

Host

Rabbit

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

This IL28RA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 387-420 amino acids from the Central region of human IL28RA.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M05986 is reactive to IFNLR1 in Human

Reconstitution

Calculated molecular weight

57653 Da

Background of IL-28R alpha/IFN-lambda R1

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M05986 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:2000

Validation Images & Assay Conditions

Gene/Protein Information For IFNLR1 (Source: Uniprot.org, NCBI)

Alternative Names

Interferon lambda receptor 1, IFN-lambda receptor 1, IFN-lambda-R1, Cytokine receptor class-II member 12, Cytokine receptor family 2 member 12, CRF2-12, Interleukin-28 receptor subunit alpha, IL-28 receptor subunit alpha, IL-28R-alpha, IL-28RA, Likely interleukin or cytokine receptor 2, LICR2, IFNLR1, IL28RA, LICR2 IFNLR1 CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2 interferon lambda receptor 1 interferon lambda receptor 1|CRF2-12|IFN-lambda receptor 1|IFN-lambda-R1|IL-28 receptor subunit alpha|IL-28R-alpha|IL-28RA|class II cytokine receptor CRF2/12|cytokine receptor class-II member 12|cytokine receptor family 2 member 12|interleukin 28 alpha receptor|interleukin 28 receptor A|interleukin 28 receptor, alpha (interferon, lambda receptor)|interleukin or cytokine receptor 2|interleukin-28 receptor subunit alpha|likely interleukin or cytokine receptor 2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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