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Product Info Summary
| SKU: | A08339 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Mouse |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-IL-31 Antibody
SKU/Catalog Number
A08339
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IL-31 Antibody (Catalog # A08339). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Mouse.
Storage & Handling
IL-31 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-IL-31 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08339)
Host
Rabbit
Contents
IL-31 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IL-31 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of mouse IL-31. The immunogen is located within amino acids 30 - 80 of IL-31.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
NETO1 antibody is predicted to not cross-react with other NETO protein family members.
Reactive Species
A08339 is reactive to IL31 in Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
18120 MW
Background of IL-31
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08339 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IL-31 antibody can be used for the detection of IL-31 by Western blot at 2.5 - 10 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5
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Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For IL31 (Source: Uniprot.org, NCBI)
Gene Name
IL31
Full Name
Interleukin-31
Weight
18120 MW
Alternative Names
1700013B14Rik, Interleukin-31, IL-31 Il31|1700013B14Rik|interleukin 31|interleukin-31|IL-31
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on IL31, check out the IL31 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IL31: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IL-31 Antibody (A08339)
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