|Product Name||Anti-IFIT2 Antibody|
|Storage & Handling||Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.|
|Description||Rabbit IgG Polyclonal antibody for IFIT2 detection. Tested with WB in Human.|
|Cite This Product||Anti-IFIT2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04428)|
|Contents/Buffer||100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide.|
|Immunogen||A partial length recombinant IFIT2 protein (amino acids 150-370).|
Assay Dilutions Overview
Western blot analysis, 2-4 μg/ml
Images And Assay Conditions
Western blot analysis of IFIT2. Anti-IFIT2 antibody was used at 4 μg/ml on Hela lysate.
Protein Target Info (Source: Uniprot.org)
|Protein Name||Interferon-induced protein with tetratricopeptide repeats 2|
|Alternative Names||Interferon-induced protein with tetratricopeptide repeats 2;IFIT-2;ISG-54 K;Interferon-induced 54 kDa protein;IFI-54K;P54;IFIT2;CIG-42, G10P2, IFI54, ISG54;|
|Subcellular Localization||Cytoplasm . Endoplasmic reticulum .|
|Molecular Weight||54632 MW|
*if product is indicated to react with multiple species, protein info is based on the human gene.
|Protein Function||IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. .|
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