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Product Info Summary
| SKU: | M00373 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, IHC-F, CyTOF |
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Product info
Product Name
Anti-Hu CD24 Purified Monoclonal Antibody
SKU/Catalog Number
M00373
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD24 Purified Monoclonal Antibody (Catalog# M00373). Tested in Flow Cytometry, IHC-F, MC (CyTOF) application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD24 Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00373)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
SN3
Isotype
Mouse IgG1
Immunogen
Glycoproteins purified from human NALM-1 cell line. The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M00373 is reactive to CD24 in Human
Reconstitution
Observed Molecular Weight
42 kDa
Calculated molecular weight
8083 MW
Background of Cd24
CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4; it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M00373 is guaranteed for Flow Cytometry, IHC-F, CyTOF Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (frozen sections): Positive tissue: tonsil.
Flow cytometry: 1-12 µg/ml
Validation Images & Assay Conditions
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Figure 1. Flow Cytometry validation of CD24 using Anti-Hu CD24 Purified Monoclonal Antibody (M00373).
Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD24 (SN3) purifiedProtein Target Info & Infographic
Gene/Protein Information For CD24 (Source: Uniprot.org, NCBI)
Gene Name
CD24
Full Name
Signal transducer CD24
Weight
8083 MW
Superfamily
CD24 family
Alternative Names
HSA, nectadorin, SCLC4 Cd24|Cd24a|CD24 molecule|signal transducer CD24|CD24 |HSA|heat-stable |nectadrin heat stable
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CD24, check out the CD24 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CD24: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Hu CD24 Purified Monoclonal Antibody (M00373)
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No publications found for M00373
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