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- Table of Contents
Facts about Signal transducer CD24.
Modulates B-cell activation answers. In association with SIGLEC10 might be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90.
Rat | |
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Gene Name: | Cd24 |
Uniprot: | Q07490 |
Entrez: | 25145 |
Belongs to: |
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CD24 family |
CD 24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD24 antigen; CD24 molecule; CD24; CD24A; CD24Asignal transducer CD24; FLJ22950; FLJ43543; MGC75043; Small cell lung carcinoma cluster 4 antigen
Mass (kDA):
7.862 kDA
Rat | |
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Location: | 20q13 |
Sequence: | 20; |
Expressed in the central nervous system, in postmitotic cells of spinal cord, hindbrain, midbrain and forebrain. Expressed in epithelium during the development of non- neural tissues. Expressed in tooth development, specifically in mesenchymal cells differentiating into odontoblast in dental papilla, as well as in the developing eye and hair follicle.
The CD24 marker is a key co-stimulatory factor in T lymphocyte homeostasis. It triggers an immune reaction against CCHFV as well as inhibits phagocytosis and acts as an adjuvant that is genetic. How is it used in a vaccine? Read on to learn more. Listed below are the best uses for CD24. Also, be sure to check out our latest video on CD24.
CD24's function in the homeostasis of T lymphocytes is a novel one. It is a co-stimulatory molecule that regulates T cell homeostasis through various mechanisms, including the ability to negatively regulate the proliferative response of antigens and the activation of dendritic cells. It plays a significant role in the regulation of immune system homeostasis by controlling inflammatory responses as well as stimulating T cell expansion.
The role of CD24 is also acknowledged as a pivotal factor in immune responses, as it is required for optimal proliferation of T cells in the lymphopenic host. Scientists have examined the interactions of CD24 and the lectins to gain a better understanding of its role in the homeostasis of T cells. These proteins act as co-stimulatory factors for CD24.
CD24 and Siglec–G interact in mice to trigger allogeneic T cell responses. Although TLR does not directly interact with CD24 however, the interaction between the two proteins could influence the immune system. In mice, the CD24-Siglec-G-dependent allogeneic response was enhanced in Siglec-G-/ mice.
CD24 is responsible for T lymphocyte homeostasis, and also regulates sympathetic axon proliferation and leukocyte homing. It also regulates the activity of the NFKB and PTK signaling pathways. CD24 also regulates the recruitment and activation of auto-reactive cells. However it also regulates T cell survival.
The study of immunology of CD24 is required to uncover the mechanisms that underlie the antigen-specificity of these cells. Therefore, it is essential to discover the function of these cells in homeostasis of the immune system. The function of regulatory T cells is vital in ensuring the effectiveness of immune and autoimmune responses. Without these cells and their immune system, the response to infection won't be possible and it will result in devastating consequences for the body.
Recent studies suggest that the CD24 marker from Boster Bio may be able to stimulate the immune system to target CCHFV which is which is a virus that infects humans and other animals. The virus is endemic in Asia and Africa, as well as Eastern Europe. It has recently been identified in the West. The virus can cause fatal, severe or even mild symptoms. Studies of epidemiology have demonstrated that it can also cause a severe, asymptomatic, and devastating reaction in humans. The vaccine is not currently available to prevent the virus from infecting the body.
When a person comes into contact with ticks that are infected The vaccine could trigger an immune response to CCHFV. Ticks are the main vectors for CCHFV. Their attachment to a human or other host susceptible to infection could increase the rate of replication. The vaccine would not only be able to stop disease, but it could also decrease viral activity and infection-associated mortality. It could also be an important tool for vector and reservoir control, and reducing the risk of transmission by zoonotics.
To test whether the CD24 marker could induce an immune response, the researchers tested a mouse model lacking in the viral sensing mechanism. Mice lacking this mechanism had less immune responses to CCHFV infections. Mice who did not have this pathway also known as IFNAR -/-, were unable to not produce any kind of IFNab receptors that are essential in the immune response to CCHFV. However, in the presence of an immune response mice lacking this mechanism would have become more sensitive to the virus.
The results indicated that CD24 is an effective genetic adjuvant. As the findings related to immune responses and cytokines are connected, it is vital to determine how this receptor is involved in the innate immune system. Further research is needed to determine whether this receptor has a direct effect on the immune system and whether there is a link between CD24 and the immune system's innate response.
Four different CCHFV strains were examined in test-of-contests using IFNAR/ mice. The isolates of the virus were utilized to identify lethal strains. The CD24-/ mice were not able to respond to the strain Ank-58. Because it performed better in SW-13 cells, the strain was chosen. It was administered two weeks after the last booster dose to assess the virus burden.
The CD24 marker that is an antigen that macrophages express on macrophages, inhibits the process of phagocytosis. The ability to prevent the process of phagocytosis is crucial for various reasons. Phagocytosis is the process through the immune cells seek out and eat cancer cells. This process is usually initiated by an antigen.
Phagocytic activity occurs when a cell absorbs the solid particles and forms an internal vesicle, known as the Phagosome. Phagocytic activity helps the immune system to eliminate pathogens and other cell debris. Phagocytic cells can be classified as different kinds of immune cells. They could be bone marrow cell, or macrophages. Phagocytic activity helps the immune system detect and eliminate pathogens as well as self-antigens.
To determine whether Boster Bio's CD24 marker inhibited phagocytosis, researchers first discovered that engineered macrophages were able to lyse established tdTomato A549 tumors. Researchers injected the donor marrow in the mice with NSG and an anti-Hum systemic antibody, and then killed them three hours later. The tumors were removed and bone marrow cells were labeled with CFDA.
This study indicates that blocking hSIRPA can enhance the stiffness and efficiency of the stiff matrix, which in turn improves the process of phagocytosis. The results from the RNA sequencing process in 4 NSG mice are presented in FIG. 12A. 12A.
PMID: 8292828 by Shirasawa T., et al. Gene expression of CD24 core peptide molecule in developing brain and developing non-neural tissues.
PMID: 9004038 by Magnaldo T.A., et al. CD24 (heat stable antigen, nectadrin), a novel keratinocyte differentiation marker, is preferentially expressed in areas of the hair follicle containing the colony-forming cells.
*More publications can be found for each product on its corresponding product page