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Product Info Summary
| SKU: | M02285-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, IP, IHC-F, ICC, WB |
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Product info
Product Name
Anti-Hu CD206 Purified MRC1 Monoclonal Antibody
View all MMR/CD206/Mannose Receptor Antibodies
SKU/Catalog Number
M02285-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD206 Purified MRC1 Monoclonal Antibody (Catalog# M02285-1). Tested in Flow Cytometry, IP, WB, IHC-F, ICC application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD206 Purified MRC1 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02285-1)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
15-2
Isotype
Mouse IgG1 kappa
Immunogen
Purified human mannose receptor. The mouse monoclonal antibody 15-2 (also known as MR15-2) recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody does not cross-react with Thy-1.1 alloantigen.
Reactive Species
M02285-1 is reactive to MRC1 in Human
Reconstitution
Observed Molecular Weight
42 kDa
Calculated molecular weight
166012 MW
Background of MMR/CD206/Mannose Receptor
CD206 (macrophage mannose receptor, MMR), also known as mannose receptor C1 (MRC1), is a type I transmembrane glycoprotein serving as pattern recognition receptor for carbogydrate groups on the surface of bacteria, fungi and other pathogens. Expressed mainly on tissue macrophages and dendritic cells, CD206 mediates endocytosis of these pathogens and presentation of their antigens to the adaptive immune system. CD206 can also be detected in a soluble form in human plasma and is elevated in patients with acute sepsis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M02285-1 is guaranteed for Flow Cytometry, IP, IHC-F, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 μg/ml.
Western blotting: 1-2 μg/ml; non-reducing conditions.
Validation Images & Assay Conditions
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Figure 1. Flow Cytometry validation of MRC1 using Anti-Hu CD206 Purified MRC1 Monoclonal Antibody (M02285-1).
Flow cytometry surface staining pattern of human stimulated monocytes (GM-CSF + IL-4) stained using anti-human CD206 (15-2) purified antibody (concentration in sample 9 μg/ml)
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Figure 2. Flow Cytometry validation of MRC1 using Anti-Hu CD206 Purified MRC1 Monoclonal Antibody (M02285-1).
Separation of human CD206 positive dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red-filled) from non-stimulated lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human stimulated monocytes (GM-CSF + IL-4) stained using anti-human CD206 (15-2) purified antibody (concentration in sample 9 μg/ml)Protein Target Info & Infographic
Gene/Protein Information For MRC1 (Source: Uniprot.org, NCBI)
Gene Name
MRC1
Full Name
Macrophage mannose receptor 1
Weight
166012 MW
Alternative Names
MMR, MRC1, CLEC13DL MRC1 CD206, CLEC13D, CLEC13DL, MMRL1, bA541I19.1, hMR, MRC1 mannose receptor C-type 1 macrophage mannose receptor 1|C-type lectin domain family 13 member D|human mannose receptor|macrophage mannose receptor 1-like protein 1|mannose receptor, C type 1-like 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MRC1, check out the MRC1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MRC1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Hu CD206 Purified MRC1 Monoclonal Antibody (M02285-1)
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