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Product Info Summary
| SKU: | M03917-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Primate |
| Host: | Mouse |
| Application: | Flow Cytometry, IHC-F, WB |
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Product info
Product Name
Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody
SKU/Catalog Number
M03917-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody (Catalog# M03917-1). Tested in Flow Cytometry, WB, IHC-F application(s). This antibody reacts with Primate, Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M03917-1)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
HP-3G10
Isotype
Mouse IgG1 kappa
Immunogen
Human NK cells. The mouse monoclonal antibody HP-3G10 recognizes an extracellular epitope of CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody does not cross-react with Thy-1.1 alloantigen.
Reactive Species
M03917-1 is reactive to KLRB1 in Human, Primate
Reconstitution
Observed Molecular Weight
42 kDa
Calculated molecular weight
25415 MW
Background of KLRB1
CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M03917-1 is guaranteed for Flow Cytometry, IHC-F, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 μg/ml.
Validation Images & Assay Conditions
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Figure 1. Flow Cytometry validation of KLRB1 using Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody (M03917-1).
Flow cytometry surface staining pattern of human peripheral blood cells stained using anti-human CD161 (HP-3G10) purified antibody (concentration in sample 4 μg/ml) GAM APC.
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Figure 2. Flow Cytometry validation of KLRB1 using Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody (M03917-1).
Separation of human CD161 positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD161 (HP-3G10) purified antibody (concentration in sample 4 μg/ml) GAM APC.Protein Target Info & Infographic
Gene/Protein Information For KLRB1 (Source: Uniprot.org, NCBI)
Gene Name
KLRB1
Full Name
Killer cell lectin-like receptor subfamily B member 1
Weight
25415 MW
Alternative Names
NKRP1A, KLRB1, CLEC5B KLRB1 CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A killer cell lectin like receptor B1 killer cell lectin-like receptor subfamily B member 1|C-type lectin domain family 5 member B|killer cell lectin-like receptor subfamily B, member 1|natural killer cell surface protein P1A
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KLRB1, check out the KLRB1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KLRB1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody (M03917-1)
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