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- Table of Contents
Facts about Killer cell lectin-like receptor subfamily B member 1.
Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation in addition to markedly increased T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope.
Human | |
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Gene Name: | KLRB1 |
Uniprot: | Q12918 |
Entrez: | 3820 |
Belongs to: |
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No superfamily |
CD161 antigen; CD161; CLEC5B; CLEC5BC-type lectin domain family 5 member B; HNKR-P1a; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B, member 1; KLRB1; Ly59; Natural killer cell surface protein P1A; NKR; NKRP1; NKR-P1; NKRP1A; NKR-P1AMGC138614; NKRP1ANKR
Mass (kDA):
25.415 kDA
Human | |
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Location: | 12p13.31 |
Sequence: | 12; NC_000012.12 (9594551..9607916, complement) |
Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Membrane; Single-pass type II membrane protein.
PMID: 8077657 by Lanier L.L., et al. Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.
PMID: 9603467 by Poggi A., et al. IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation.