Killer cell lectin-like receptor subfamily B member 1 (KLRB1)

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in certain acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide.

Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation in addition to markedly increased T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope.