Anti-Hu CD117 Purified KIT Monoclonal Antibody

Product Name

Anti-Hu CD117 Purified KIT Monoclonal Antibody

View all CD117/c-kit Antibodies

SKU/Catalog Number

M01335-3

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD117 Purified KIT Monoclonal Antibody (Catalog# M01335-3). Tested in Flow Cytometry, IP, IHC-F, ICC application(s). This antibody reacts with Primate, Human, Cow.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD117 Purified KIT Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01335-3)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

104D2

Isotype

Mouse IgG1 kappa

Immunogen

MOLM-1 megakaryocytic cells. The mouse monoclonal antibody 104D2 detects extracellular part of CD117 / c-Kit protooncogen.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M01335-3 is reactive to KIT in Cow, Human, Primate

Reconstitution

Observed Molecular Weight

42 kDa

Calculated molecular weight

109865 MW

Background of CD117/c-kit

CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M01335-3 is guaranteed for Flow Cytometry, IP, IHC-F, ICC Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 1 μg/ml.

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For KIT (Source: Uniprot.org, NCBI)

Alternative Names

c-Kit, PBT, SCFR KIT C-Kit, CD117, MASTC, PBT, SCFR KIT proto-oncogene, receptor tyrosine kinase mast/stem cell growth factor receptor Kit|c-Kit protooncogene|p145 c-kit|piebald trait protein|proto-oncogene c-Kit|proto-oncogene tyrosine-protein kinase Kit|soluble KIT variant 1|tyrosine-protein kinase Kit|v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog|v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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