Product Info Summary
SKU: | A00568-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | IF, WB |
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Product info
Product Name
Anti-HLA-DRB1 Antibody
SKU/Catalog Number
A00568-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-HLA-DRB1 Antibody catalog # A00568-1. Tested in WB,IF applications. This antibody reacts with Human,Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-HLA-DRB1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00568-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human TRPV4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00568-1 is reactive to HLA-DRB1 in Human, Mouse
Applications
A00568-1 is guaranteed for IF, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
29966 MW
Background of HLA-DRB1
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes By similarity. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Nagamine K., Nat. Genet. 17:393-398(1997).
Aaltonen J., Nat. Genet. 17:399-403(1997).
Hattori M., Nature 405:311-319(2000).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2000
IF: 1:50-1:100
Validation Images & Assay Conditions
![a00568 1 anti hla drb1 antibody if testing 2 a00568 1 anti hla drb1 antibody if testing 2](https://www.bosterbio.com/media/catalog/product/a/0/a00568-1-anti-hla-drb1-antibody-if-testing-2.jpg)
Click image to see more details
Figure 2. Immunofluorescent staining data of HLA-DRB1 using Anti-HLA-DRB1 Antibody (A00568-1).
Immunofluorescence analysis of A549 cells using HLA-DRB1 antibody.![a00568 1 anti hla drb1 antibody wb testing 1 a00568 1 anti hla drb1 antibody wb testing 1](https://www.bosterbio.com/media/catalog/product/a/0/a00568-1-anti-hla-drb1-antibody-wb-testing-1.jpg)
Click image to see more details
Figure 1. Western blotting validation for Anti-HLA-DRB1 Antibody A00568-1
Western blot analysis of extracts of various cell linesProtein Target Info & Infographic
Gene/Protein Information For HLA-DRB1 (Source: Uniprot.org, NCBI)
Gene Name
HLA-DRB1
Full Name
HLA class II histocompatibility antigen, DRB1 beta chain
Weight
29966 MW
Alternative Names
Clone P2-beta-3; DR1; DR-1; DR12; DR-12; DR13; DR-13; DR14; DR-14; DR16; DR-16; DR4; DR-4; DR5; DR-5; DR7; DR-7; DR8; DR-8; DR9; DR-9; DRB1; DRw10; DRw11; DRw8; DW2.2/DR2.2; FLJ75017; FLJ76359; HLA class II antigen beta chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-DR1B; HLA-DRB; HLA-DRB1*; HLA-DRB2; HLA-DR-beta 1; human leucocyte antigen DRB1; leucocyte antigen DR beta 1 chain; leucocyte antigen DRB1; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1; MHC class II antigen DRB1*1; MHC class II antigen DRB1*10; MHC class II antigen DRB1*11; MH HLA-DRB1 DRB1, HLA-DR1B, HLA-DRB, SS1 major histocompatibility complex, class II, DR beta 1 major histocompatibility complex, class II, DR beta 1 precursor|HLA class II histocompatibility antigen, DR-1 beta chain|MHC class II HLA-DR beta 1 chain|human leucocyte antigen DRB1|lymphocyte antigen DRB1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HLA-DRB1, check out the HLA-DRB1 Infographic
![HLA-DRB1 infographic](/media/images/gene-infographic-example.jpg)
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HLA-DRB1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-HLA-DRB1 Antibody (A00568-1)
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