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Product Info Summary
| SKU: | A01658 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-HAP1 Antibody
SKU/Catalog Number
A01658
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-HAP1 Antibody (Catalog # A01658). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
HAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-HAP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01658)
Host
Rabbit
Contents
HAP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
HAP1 antibody was raised against a 19 amino acid synthetic peptide from near the center of human HAP1. The immunogen is located within amino acids 310 - 360 of HAP1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.
Reactive Species
A01658 is reactive to HAP1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
75506 MW
Background of HAP1
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01658 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
HAP1 antibody can be used for detection of HAP1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemistry of HAP1 in human brain tissue with HAP1 antibody at 2.5 μg/mL.
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Immunofluorescence of HAP1 in Human Brain cells with HAP1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For HAP1 (Source: Uniprot.org, NCBI)
Gene Name
HAP1
Full Name
Huntingtin-associated protein 1
Weight
75506 MW
Alternative Names
HLP, HAP2, HIP5, hHLP1, HLP1, Huntingtin-associated protein 1, Neuroan 1, HAP-1 HAP1 HAP2, HIP5, HLP, hHLP1 huntingtin associated protein 1 huntingtin-associated protein 1|HAP-1|epididymis secretory sperm binding protein|huntingtin-associated protein 2|neuroan 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HAP1, check out the HAP1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HAP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-HAP1 Antibody (A01658)
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