HAP1 Antibodies

Huntingtin-associated protein 1 (HAP1)

Initially identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. The two HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to connect HTT to motor proteins and/or transport cargos.

Seems to play a role in vesicular transport within neurons and axons like from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT.

Gene Information

Human
Gene Name:	HAP1
Uniprot:	P54257
Entrez:	9001

Family

Belongs to:
No superfamily

Alternative Names

HAP2huntingtin-associated protein 2; hHLP1; HIP5; HLP1; HLPHAP-1; huntingtin-associated protein 1; Neuroan 1

Molecular Weight

Mass (kDA):
75.506 kDA

Genomic Context

Human
Location:	17q21.2
Sequence:	17; NC_000017.11 (41717739..41734646, complement)

Tissue Specificity

Predominantly expressed in brain. Selectively expressed in neurons.

Subcellular Localizations

Cytoplasm. Cell projection, axon. Cell junction, synapse, presynapse. Cytoplasm, cytoskeleton. Cell projection, dendritic spine. Cell projection, dendrite. Lysosome. Endoplasmic reticulum. Mitochondrion. Nucleus. Cytoplasmic vesicle, autophagosome. Early endosome. Cell projection, growth cone. Cell projection, neuron projection. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Localizes to large nonmembrane-bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs). Localization to neuronal processes and neurite tips is decreased by YWHAZ. In the nucleus

Diseases

• Huntington Disease
• Neoplasms
• Malignant Neoplasms
• Salmonella Infections
• Hypoxia
• Neurodegenerative Disorders
• Carcinoma
• Neuropathology Disease
• Nerve Degeneration
• Nervousness
• Dysequilibrium Syndrome
• Leptospirosis
• Lung Neoplasms

• Atrophy
• Malnutrition
• Melanoma
• Melanoma, Experimental
• Neuroblastoma
• Skin Neoplasms
• Atherosclerosis

Interacting Proteins

• AHI1
• HTT

Pathways

• Transport
• Dna Repair
• Localization
• Pathogenesis
• Endocytosis
• Cell Death
• Neurogenesis
• Translation
• Feeding Behavior
• Fermentation
• Cell Cycle
• Secretion
• Spermatogenesis

• Brain Development
• Virulence
• Synaptic Transmission
• Cell Growth
• Cell Differentiation
• Chromatin Remodeling
• Cell Proliferation

PTMs

• Cleavage
• Reduction
• Phosphorylation
• Methylation

• Oxidation
• Sumoylation
• Deamination
• Dephosphorylation

• Ubiquitination

Research Areas

• Autophagy
• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HAP1

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