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Product Info Summary
| SKU: | A10482 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-HAAO Antibody
SKU/Catalog Number
A10482
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-HAAO Antibody (Catalog # A10482). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
HAAO antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-HAAO Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10482)
Host
Rabbit
Contents
HAAO Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
HAAO antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human HAAO. The immunogen is located within amino acids 30 - 80 of HAAO.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody is specific for RKHD3 and will not recognize the other RKHD3 family of proteins.
Reactive Species
A10482 is reactive to HAAO in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
32556 MW
Background of HAAO
HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A10482 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
HAAO antibody can be used for detection of HAAO by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Validation Images & Assay Conditions
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Western blot analysis of HAAO in Mouse liver tissue lysate with HAAO antibody at 1 μg/mL.
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Immunohistochemistry of HAAO in human liver tissue with HAAO antibody at 2.5 μg/mL.
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Immunofluorescence of HAAO in Human Liver cells with HAAO antibody at 20 μg/mL.
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Immunohistochemistry of HAAO in mouse colon tissue with HAAO antibody at 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For HAAO (Source: Uniprot.org, NCBI)
Gene Name
HAAO
Full Name
3-hydroxyanthranilate 3,4-dioxygenase
Weight
32556 MW
Superfamily
3-HAO family
Alternative Names
HAO, 3-HAO, 3-hydroxyanthranilate 3, 4-dioxygenase, 3-hydroxyanthranilate oxygenase HAAO 3-HAO, HAO, VCRL1, h3HAO 3-hydroxyanthranilate 3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase|3-hydroxyanthranilate oxygenase|3-hydroxyanthranilic acid dioxygenase|HAD
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HAAO, check out the HAAO Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HAAO: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-HAAO Antibody (A10482)
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